Smoothened
Smoothened is a G protein-coupled receptor of the hedgehog signaling pathway.
Products for Smoothened
- Cat.No. Product Name Information
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GC15422
20(S)-Hydroxycholesterol
20α-hydroxy Cholesterol
An allosteric activator of the oncoprotein smoothened (Smo) -
GC14749
ALLO-1
ALLO-1, an autophagy receptor, is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 through its LC3-interacting region (LIR) motif.
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GC34463
ALLO-2
ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.
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GC13628
BMS-833923
BMS 833923;BMS833923;XL-139;XL139;XL 139
An orally bioavailable Smo inhibitor -
GC11217
CUR 61414
G-856
potent inhibitor of hedgehog-induced cellular activity -
GC50685
Dynapyrazole A
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GC50486
Dynarrestin
Inhibitor of Hedgehog (Hh) signaling; inhibits cytoplasmic dynein
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GC14640
GSA 10
Smoothened (Smo) receptor agonist
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GC14896
Halcinonide
SQ 18,566
Anti-inflammatory agent -
GC12951
HhAntag
A hedgehog pathway inhibitor
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GC50203
IHR-Cy3
Potent fluorescent Smo antagonist
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GC11111
Jervine
NSC 7520, NSC 23898
Hedgehog signaling Inhibitor -
GC13655
LDE225 (NVP-LDE225,Erismodegib)
LDE225 (NVP-LDE225,Erismodegib) (Erismodegib) is a potent and selective Smo antagonist with IC50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively.
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GC14169
LDE225 Diphosphate
LDE 225 Diphosphate;NVP-LDE 225 Diphosphate;Erismodegib Diphosphate;LDE-225 Diphosphate
A Smo antagonist -
GC32954
LEQ506 (NVP-LEQ506)
NVP-LEQ506
LEQ506 (NVP-LEQ506) is a second-generation inhibitor of smoothened (Smo) with IC50s of 2 and 4 nM in human and mouse, respectively. -
GC15683
LY2940680
Taladegib
LY2940680 (LY2940680) is an antagonist of the smoothened receptor. -
GC13041
M 25
Smoothened (Smo) receptor antagonist
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GC13630
MK-4101
Hedgehog (Hh) signaling pathway inhibitor
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GC12192
MRT 10
MRT 10 is a seven-transmembrane receptor smoothened (Smo) antagonist with an IC50 of 0.65 μM in the micromolar range in various Hedgehog (Hh) assays. MRT 10 binds to the Smo receptor at the level of the Bodipycyclopamine binding site. MRT 10 can be used for the research of cancer.
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GC64419
MRT-14
MRT-14 is a potent antagonist of Smo. Smo is the major component involved in signal transduction of the Hedgehog (Hh) morphogens. MRT-14 has the potential for the research of several types of cancers linked to abnormal Hh signaling.
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GC63336
MRT-81
MRT-81 is a potent antagonist of human and rodent smoothened (Smo) receptors, with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer.
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GC33114
MRT-83
MRT-83 is a potent antagonist of Smo, with an IC50 in the nanomolar range. MRT-83 also blocks Hedgehog (Hh) signaling.
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GC63863
MRT-83 hydrochloride
MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease.
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GC16230
PF-04449913
Glasdegib
PF-04449913 (PF-04449913) is a potent and orally bioavailable smoothened inhibitor. PF-04449913 (PF-04449913) binds to human SMO (amino acids 181-787) with an IC50 of 4 nM. -
GC18599
PF-05274857 (hydrochloride)
PF-05274857 (hydrochloride) is a potent, selective, orally active and brain-penetrant antagonist of Smo, with an IC50 of 5.8 nM and Ki of 4.6 nM. PF-05274857 (hydrochloride) has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway.
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GC13280
PF-5274857
Smo antagonist,potent and selective
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GC15064
Purmorphamine
Purmorphamine is the first small molecule agonist developed for Smoothened protein.
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GC12068
SAG
Smoothened Agonist
SAG (Smoothened Agonist) is an effective Smo receptor agonist. -
GC50135
SAG 21k
Hedgehog signaling activator; brain penetrant and orally bioavailable
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GC37580
SAG hydrochloride
SAG hydrochloride is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG hydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine inhibition of Smo.
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GC62258
SAG-d3
SAG-d3 is deuterium labeled SAG. SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM).
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GC15889
SANT-1
Shh inhibitor,potent and cell-permeable
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GC32978
Saridegib (IPI-926)
IPI-926; Patidegib
Saridegib (IPI-926) is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway. -
GC12228
SMANT hydrochloride
Smoothened (Smo) signaling inhibitor
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GC73310
SMO-IN-2
SMO-IN-2 (compound 1) is a potent smoothened (SMO) inhibitor with an IC50 value of 123.4 nM for hedgehog (Hh) signaling pathway.