GLPBio

FAK

FAK (focal adhesion kinase), also known as PTK2, is a focal adhesion-associated protein kinase involved in cellular adhesion and spreading processes.

Products Related to FAK(45)

  • GC64015 structure
    GC64015AMP-945
    CAS: 1393653-34-3
    Purity: >98.00%

    AMP-945 is an inhibitor of the enzyme focal adhesion kinase (FAK).

  • GC64377 structure
    GC64377Batatasin III
    CAS: 56684-87-8
    Purity: >99.00%

    Batatasin III, a stilbenoid, inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition (EMT) and FAK-AKT signals. Batatasin III has anti-cancer activities.

  • GC64888 structure
    GC64888GSK215
    CAS: 2743427-26-9
    Purity: >99.00%

    GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader with a pDC50 of 8.4. GSK215 is designed by a binder for the VHL E3 ligase and the FAK inhibitor VS-4718. GSK215 induces rapid and prolonged FAK degradation, giving a long-lasting effect on FAK levels and a marked pharmacokinetic/pharmacodynamics (PK/PD) disconnect.

  • GC64992 structure
    GC64992YH-306
    CAS: 1373764-75-0
    Purity: >98.00%

    YH-306 is an antitumor agent. YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. YH-306 significantly inhibits the migration and invasion of colorectal cancer cells. YH-306 potently suppresses uninhibited proliferation and induces cell apoptosis. YH-306 suppresses the activation of FAK, c-Src, paxillin, and PI3K, Rac1 and the expression of MMP2 and MMP9. YH-306 also inhibita actin-related protein (Arp2/3) complex-mediated actin polymerization.

  • GC65457 structure
    GC65457BI-3663
    CAS: 2341740-84-7
    Purity: >99.00%

    BI-3663 is a highly selective PTK2/FAK PROTAC (DC50=30 nM), with Cereblon ligands to hijack E3 ligases for PTK2 degradation. BI-3663 inhibits PTK2 with an IC50 of 18 nM. BI-3663 is a PROTAC that composes of BI-4464 linked to Pomalidomide with a linker. Anti-cancer activity.

  • GC65886 structure
    GC65886BI-853520
    CAS: 1227948-82-4
    Purity: >98%

    BI 853520 (IN-10018) is an orally active and potent focal adhesion kinase (FAK) inhibitor (recombinant FAK IC50=1nM). BI 853520 shows anti-proliferative activity against cancer cells.

  • GC68030 structure
    GC68030FAK-IN-7
    CAS: 19948-85-7
    Purity: >98%
  • GC68463 structure
    GC68463ULK1-IN-2
    CAS: 2497409-01-3
    Purity: >98%
  • GC68626 structure
    GC68626Adhesamine
    CAS: 462605-73-8
    Purity: >95.00%

    Adhesamine is a dumbbell-shaped molecule that can activate the MAPK/FAK pathway. Adhesamine promotes adhesion and growth of mammalian cells. Adhesamine accelerates differentiation of primary cultured mouse hippocampal neurons and improves survival rate.

  • GC72932 structure
    GC72932Adhesamine diTFA
    CAS: 1201698-09-0

    Adhesamine diTFA is a dumbbell-shaped molecule that activates the MAPK/FAK pathway.

  • GC73041 structure
    GC73041ZINC40099027
    CAS: 1211825-25-0
    Purity: >98.00%

    ZINC40099027 is a FAK activator.

  • GC73149 structure
    GC73149FLT3-IN-17
    CAS: 2758999-62-9
    Purity: >99.00%

    FLT3-IN-17 inhibits CYPs and FLT3 mutants activity (IC50s: <0.5 nM for D835Y).

  • GC73424 structure
    GC73424PRT062607 acetate
    CAS: 1370261-98-5
    Purity: >99.00%

    PRT062607 (P505-15) acetate is an orally available Syk inhibitor (IC50: 1 nM) that inhibits inflammation and induction Apoptosis.

  • GC73575 structure
    GC73575FAK-IN-14
    CAS: 2766666-22-0
    Purity: >99.00%

    FAK-IN-14 (compound 8d) is a focal adhesion kinase(FAK) inhibitor with an IC50 value of 0.2438 nM.

  • GC74116 structure
    GC74116Pyk2-IN-2
    CAS: 1271418-15-5
    Purity: >98.00%

    Pyk2-IN-2 (compound 13j) is an inhibitor of Pyk2 with an IC50 of FAK kinase of 0.608 μM.

  • GC79141 structure
    GC79141T7 Peptide TFA
    Purity: >98.00%

    T7 Peptide TFA is a protein synthesis inhibitor and anti-angiogenic agent, with a K d of 10 nM for human transferrin receptor.

  • GC79423 structure
    GC79423IL13Rα2 D1
    CAS: 2319573-67-4
    Purity: >99.00%

    IL13Rα2 D1 is an effective IL-13/IL13Rα2 signaling axis inhibitor.

  • GC81301 structure
    GC81301BSJ-04-146
    CAS: 2414478-45-6
    Purity: >98%

    BSJ-04-146 is a highly efficient and selective PROTAC targeting focal adhesion kinase ( FAK ) inhibitor( IC 50 = 26 nM).

  • GC81313 structure
    GC81313STARD3-IN-1
    CAS: 1424357-72-1
    Purity: >99.00%

    STARD3-IN-1 (Compound VS1) is a STARD3 inhibitor with an IC₅₀ of 35 μM.

  • GC81328 structure
    GC81328GZD-552
    Purity: >98%

    GZD-552 is a potent orally active FAK inhibitor with a human FAK IC 50 of 5.8 nM.

  • GC81556 structure
    GC81556FZ1 peptide
    Purity: >99.50%

    FZ1 peptide is a cyclic heptapeptide and also an integrin αvβ3 agonist.