FZ1 peptide |
Catalog No.GC81556
One-Click Copy Product Info
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FZ1 peptide is a cyclic heptapeptide and also an integrin αvβ3 agonist.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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In Vivo, FZ1 peptide (topical) significantly accelerates wound closure in infected diabetic C57BL/6 mice, achieving 92.01% closure by day 21 alongside improved re-epithelialization, granulation tissue formation, and collagen deposition[1].
In Vitro, FZ1 peptide (10 nM) shows the highest drug loading content (12.26%) and drug loading efficiency (83.12%) among all tested formulations when incorporated into the 4% (w/v) HA-c-FZ1 hydrogel[1]. FZ1 peptide (2-4% (w/v)) is released from HA-c-FZ1 hydrogel in a pH-dependent manner, with an accelerated release rate under acidic conditions matching the early inflammatory phase of diabetic wounds, which supports pathologically coupled peptide delivery[1]. FZ1 peptide (2-4% (w/v); 24 h) shows no cytotoxicity to HaCaT keratinocytes, HSFs, RAW264.7 macrophages and HUVECs in HA-c-FZ1 hydrogel extracts, and the 4% formulation significantly promotes cell proliferation[1]. FZ1 peptide (4% (w/v)) activates the pro-angiogenic signaling pathways of ERK, AKT, and FAK in HUVECs within HA-c-FZ1 hydrogel extracts[1]. FZ1 peptide (2-4% (w/v)) exhibits antibacterial activity against S. aureus and E. coli in extracts of HA-c-FZ1 hydrogels; it inhibits LPS-induced secretion of proinflammatory cytokines (IL-6, TNF-α) in RAW264.7 macrophages in a concentration-dependent manner; it reduces intracellular ROS levels in H2O2-treated HUVECs in a concentration-dependent manner; and it promotes migration of HaCaT keratinocytes and increases the healing rate of scratch wounds[1].
References:
[1]. Fu Z, et al. Multifunctional pH-responsive HA-c-FZ1 hydrogel presents a promising therapeutic strategy for diabetic skin wounds. Burns & Trauma, 2026, tkog046.
[2]. Wang L, et al. Cyclic Heptapeptide FZ1 Acts as an Integrin αvβ3 Agonist to Facilitate Diabetic Skin Wound Healing by Enhancing Angiogenesis. Journal of medicinal chemistry. 2025 Sep 25;68(18):19503-19520.
| Cas No. | SDF | ||
| Formula | C29H49N9O12S2 | M.Wt | 779.88 |
| Solubility | H2O: ≥ 100 mg/mL (128.22 mM) | Storage | Sealed storage, away from moisture and light |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.2822 mL | 6.4112 mL | 12.8225 mL |
| 5 mM | 256.4 μL | 1.2822 mL | 2.5645 mL |
| 10 mM | 128.2 μL | 641.1 μL | 1.2822 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.50% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)