RSK-IN-2 (Compound 3e) is a RSK inhibitor, with IC50 s of 37.89 nM ( RSK2 ), 30.78 nM (RSK1), 20.51 nM ( RSK3 ), 91.28 nM ( RSK4 ). RSK-IN-2 inhibits tumor cell proliferation, induces apoptosis and causes cell cycle arrest in the G2/M phase [1].
References:
[1]. Han C, et al. Discovery of 2,4-dianilinopyrimidine derivatives as novel p90 ribosomal S6 protein kinase (RSK) inhibitors. Eur J Med Chem. 2025 Jul 5;291:117590.
References:
[1]. Han C, et al. Discovery of 2,4-dianilinopyrimidine derivatives as novel p90 ribosomal S6 protein kinase (RSK) inhibitors. Eur J Med Chem. 2025 Jul 5;291:117590.