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SI-2 (Synonyms: EPH 116)

Catalog No.GC44888

SI-2 is an inhibitor of steroid receptor coactivator 3 (SRC-3).

Products are for research use only. Not for human use. We do not sell to patients.

SI-2 Chemical Structure

Cas No.: 380537-35-9

Size Price Stock Qty
1mg
$60.00
In stock
5mg
$225.00
In stock
10mg
$419.00
In stock
25mg
$974.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

SI-2 is an inhibitor of steroid receptor coactivator 3 (SRC-3). It has been shown to selectively reduce the transcriptional activities and the protein concentrations of SRC-3 in cells through direct physical interactions with SRC-3.1 SI-2 induces death in various breast cancer cells with IC50 values of 3-20 nM without affecting normal cell viability.[1] At 2 mg/kg, SI-2 can also inhibit primary tumor growth and reduce SRC-3 protein levels in an MDA-MB-468 breast cancer mouse model.[1]

Reference:
[1]. Song, X., Chen, J., Zhao, M., et al. Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proceedings of the National Academy of Sciences of the United States of America 113(18), 4970-4975 (2016).

Chemical Properties

Cas No. 380537-35-9 SDF
Synonyms EPH 116
Chemical Name (1E)-1-(2-pyridinyl)-ethanone-2-(1-methyl-1H-benzimidazol-2-yl)hydrazone
Canonical SMILES C/C(C1=NC=CC=C1)=N\NC2=NC3=C(C=CC=C3)N2C
Formula C15H15N5 M.Wt 265.3
Solubility 20mg/mL in ethanol, 30mg/mL in DMSO or DMF Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.7693 mL 18.8466 mL 37.6932 mL
5 mM 0.7539 mL 3.7693 mL 7.5386 mL
10 mM 0.3769 mL 1.8847 mL 3.7693 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 22 reference(s) in Google Scholar.)

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