Siaresinolic acid is a compound found in the leaves of Sabicea grisea. Siaresinolic acid shows antinociceptive and anti-inflammatory activity. Siaresinolic acid reduces nociceptive behavior by ATP-dependent potassium channel, inhibits leukocyte influx, plasma leakage, and proinflammatory mediator ( TNF-α, IL-1β ) production. Siaresinolic acid does not induce cytotoxicity in murine macrophages, alter locomotor activity at high doses. Siaresinolic acid can be used for the research of pleurisy and pain [1].
In Vivo, Siaresinolic acid (0.1-10 mg/kg; i.p.; 1 hour before acetic acid injection) produces dose-dependent peripheral antinociception in the Acetic acid -induced writhing model, with a maximum 70.9% inhibition at 10 mg/kg[1]. Siaresinolic acid (1 mg/kg; i.p.; 1 hour before formalin injection) selectively inhibits the inflammatory phase of formalin-induced nociception in mice[1]. Siaresinolic acid (0.01-1 mg/kg; i.p.; 1 hour before carrageenan injection) dose-dependently inhibits acute inflammatory responses in Carrageenan -induced pleurisy, with 1 mg/kg producing >82% inhibition of key proinflammatory mediators[1]. Siaresinolic acid (1 mg/kg; i.p.) does not produce central antinociception in the hot plate test in mice[1].
In Vitro, Siaresinolic acid (1-200 μg/mL; 24 h) is non-cytotoxic to murine peritoneal macrophages[1].
References:
[1]. de Oliveira AM, et al. Antinociceptive and anti-inflammatory activity of the siaresinolic acid, a triterpene isolated from the leaves of Sabicea grisea Cham. & Schltdl. var. grisea. J Nat Med. 2015;69(2):232-240.
In Vivo, Siaresinolic acid (0.1-10 mg/kg; i.p.; 1 hour before acetic acid injection) produces dose-dependent peripheral antinociception in the Acetic acid -induced writhing model, with a maximum 70.9% inhibition at 10 mg/kg[1]. Siaresinolic acid (1 mg/kg; i.p.; 1 hour before formalin injection) selectively inhibits the inflammatory phase of formalin-induced nociception in mice[1]. Siaresinolic acid (0.01-1 mg/kg; i.p.; 1 hour before carrageenan injection) dose-dependently inhibits acute inflammatory responses in Carrageenan -induced pleurisy, with 1 mg/kg producing >82% inhibition of key proinflammatory mediators[1]. Siaresinolic acid (1 mg/kg; i.p.) does not produce central antinociception in the hot plate test in mice[1].
In Vitro, Siaresinolic acid (1-200 μg/mL; 24 h) is non-cytotoxic to murine peritoneal macrophages[1].
References:
[1]. de Oliveira AM, et al. Antinociceptive and anti-inflammatory activity of the siaresinolic acid, a triterpene isolated from the leaves of Sabicea grisea Cham. & Schltdl. var. grisea. J Nat Med. 2015;69(2):232-240.