SL 01 is a prodrug of gemcitabine , the nucleoside analog used intravenously to treat various cancers that was designed for improved oral bioavailability. SL 01 can inhibit the growth of human non-small cell lung cancer NCI-H460 cells, colon cancer HCT116 cells, and breast cancer MCF-7 cells (IC50s = 0.78, 0.92, and 0.64 μM, respectively), inducing apoptosis. In nude mice bearing NCI-H460, HCT116, or MCF-7 cancer cell xenografts, SL 01 at 10-50 μM/kg has been shown to delay tumor growth.
SL 01
Catalog No.: GC44897Purity:>98.00%Synonyms: NSC 251810, SL 01, Z-L-Phe Chloromethyl Ketone, ZPCK
SL 01 is an oral active prodrug of gemcitabine that was designed for improved oral bioavailability.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 26049-94-5
250mgIn Stock
$57.00
1
500mgIn Stock
$105.00
1
1gIn Stock
$143.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 250mg | $57.00 | In Stock | 1 | |
| 500mg | $105.00 | In Stock | 1 | |
| 1g | $143.00 | In Stock | 1 |
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Citations
No citations are currently available for this product. Below are selected publications citing GlpBio products.
Nature641, 529–536 (2025)
Nature628, 630–638 (2024)
Nature632, 686–694 (2024)
Nature618, 1017–1023 (2023)
Nature610, 366–372 (2022)
Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
Science388(6745) (2025)
Science387(6739) (2025)
Science387(6734) (2025)
Cell Research35, 97–116 (2025)
Cell Research34, 683–706 (2024)
Cell Research33, 273–287 (2023)
Cell Research33, 546–561 (2023)
Cell Research33, 904–922 (2023)
Cell Research31, 1291–1307 (2021)
Description
Product Documents
Purity:>98.00%Appearance:A solid
Chemical Properties
CAS No.
26049-94-5
Synonyms
NSC 251810, SL 01, Z-L-Phe Chloromethyl Ketone, ZPCK
SMILES
O=C(CCl)[C@@H](NC(OCC1=CC=CC=C1)=O)CC2=CC=CC=C2
Molecular Formula
C18H18ClNO3
Molecular Weight
331.8
Solubility
DMF: 33 mg/ml,DMSO: 33 mg/ml,DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml,Ethanol: 2 mg/ml
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
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