Apatorsen (Synonyms: OGX-427) |
| Catalog No.GC65035 |
Apatorsen es un oligonucleÓtido antisentido diseÑado para unirse al ARNm de Hsp27, lo que da como resultado la inhibiciÓn de la producciÓn de la proteÍna Hsp27.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1002331-21-6
Sample solution is provided at 25 µL, 10mM.
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Apatorsen is an antisense oligonucleotide designed to bind to Hsp27 mRNA, resulting in the inhibition of the production of Hsp27 protein.
[1]. Spigel DR, Shipley DL, Waterhouse DM, et al. A Randomized, Double-Blinded, Phase II Trial of Carboplatin and Pemetrexed with or without Apatorsen (OGX-427) in Patients with Previously Untreated Stage IV Non-Squamous-Non-Small-Cell Lung Cancer: The SPRUCE Trial. Oncologist. 2019;24(12):e1409-e1416. [2]. Yu EY, Ellard SL, Hotte SJ, et al. A randomized phase 2 study of a HSP27 targeting antisense, apatorsen with prednisone versus prednisone alone, in patients with metastatic castration resistant prostate cancer. Invest New Drugs. 2018;36(2):278-287.
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