BCI-215 |
| Catalog No.GC39160 |
BCI-215 es un potente inhibidor de la fosfatasa MAPK de doble especificidad (DUSP-MKP) selectivo para células tumorales. BCI-215 tiene citotoxicidad para las células tumorales pero no para las células normales.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1245792-67-9
Sample solution is provided at 25 µL, 10mM.
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BCI-215 is a potent and tumor cell-selective dual specificity MAPK phosphatase (DUSP-MKP) inhibitor. BCI-215 has cytotoxicity for tumor cells but not normal cells[1][2].
[1]. Korotchenko VN, et al. In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase. Chembiochem. 2014 Jul 7;15(10):1436-45. [2]. Kaltenmeier CT, et al. A Tumor Cell-Selective Inhibitor of Mitogen-Activated Protein Kinase Phosphatases Sensitizes Breast Cancer Cells to Lymphokine-Activated Killer Cell Activity. J Pharmacol Exp Ther. 2017 Apr;361(1):39-50.
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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