BNC105 |
| Catalog No.GC34102 |
BNC105 es un inhibidor de la polimerizaciÓn de tubulina con potentes propiedades antiproliferativas y disruptoras vasculares tumorales.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 945771-74-4
Sample solution is provided at 25 µL, 10mM.
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BNC105 is a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.
[1]. Flynn BL, et al. Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. J Med Chem. 2011 Sep 8;54(17):6014-27. [2]. Kremmidiotis G, et al. BNC105: a novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacy. Mol Cancer Ther. 2010 Jun;9(6):1562-73. [3]. Inglis DJ, et al. The vascular disrupting agent BNC105 potentiates the efficacy of VEGF and mTOR inhibitors in renal and breast cancer. Cancer Biol Ther. 2014;15(11):1552-60.
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