BRD4 degrader-7 (Compound ZZ1) is a CTLH -dependent BRD4 degrader and c-Glue with a DC50 of 489 nM. BRD4 degrader-7 converts to a sulfinic acid derivative inside cells, interacts with the basic pocket of YPEL5, mediates the bridging of BRD4 BD1 to the YPEL5 subunit of the CTLH E3 ubiquitin ligase, and thereby promotes the formation of a ternary complex. BRD4 degrader-7 can be used in research on Ewing's sarcoma and leukemia [1].
In Vitro, BRD4 degrader-7 (ZZ1) (10-10000 nM; 5 h) potently induces proteasome-dependent degradation of BRD4 in Jurkat cells via a non-CRL E3 ligase pathway, with a DC50 of 502 nM[1]. BRD4 degrader-7 (10-10000 nM; 5 h) induces BRD4 degradation in Jurkat cells, with a DC50 of 489 nM[1].
References:
[1]. Zhuang Z, et al. Charged molecular glue discovery enabled by targeted degron display. Nat Chem Biol. Published online April 6, 2026.
In Vitro, BRD4 degrader-7 (ZZ1) (10-10000 nM; 5 h) potently induces proteasome-dependent degradation of BRD4 in Jurkat cells via a non-CRL E3 ligase pathway, with a DC50 of 502 nM[1]. BRD4 degrader-7 (10-10000 nM; 5 h) induces BRD4 degradation in Jurkat cells, with a DC50 of 489 nM[1].
References:
[1]. Zhuang Z, et al. Charged molecular glue discovery enabled by targeted degron display. Nat Chem Biol. Published online April 6, 2026.