Escholtzine perchlorate is an Alkaloid. Escholtzine perchlorate can be isolated from Eschscholzia californica. Escholtzine perchlorate is a CYP3A4 inhibitor, 5-HT 1A receptor inhibitor with a CYP3A4 IC50 of 13.4 μM, 5-HT 1A EC 50 of 11 μM. Escholtzine perchlorate can be used for the research of anxiety, depression [1] [2].
In Vitro, Escholtzine (60 min) perchlorate weakly inhibits the binding of [3H]8-OH-DPAT to human recombinant 5-HT1A receptors, with an EC50 of 11 μM and a Ki of 6 μM[1]. Escholtzine (1 h) perchlorate potently inhibits CYP3A4 enzyme activity in vitro, with an IC50 value of 13.4 μM[1].
References:
[1]. Gafner S, et al. Alkaloids from Eschscholzia californica and their capacity to inhibit binding of [3H]8-Hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A receptors in Vitro. J Nat Prod. 2006 Mar;69(3):432-5.
[2]. Cahlíková L, et al. Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Eschscholzia californica (Papaveraceae). Nat Prod Commun. 2010;5(7):1035-1038.
In Vitro, Escholtzine (60 min) perchlorate weakly inhibits the binding of [3H]8-OH-DPAT to human recombinant 5-HT1A receptors, with an EC50 of 11 μM and a Ki of 6 μM[1]. Escholtzine (1 h) perchlorate potently inhibits CYP3A4 enzyme activity in vitro, with an IC50 value of 13.4 μM[1].
References:
[1]. Gafner S, et al. Alkaloids from Eschscholzia californica and their capacity to inhibit binding of [3H]8-Hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A receptors in Vitro. J Nat Prod. 2006 Mar;69(3):432-5.
[2]. Cahlíková L, et al. Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Eschscholzia californica (Papaveraceae). Nat Prod Commun. 2010;5(7):1035-1038.