Forodesine hydrochloride (BCX-1777) (Synonyms: BCX-1777 hydrochloride; Immucillin-H hydrochloride) |
| Catalog No.GC32708 |
El clorhidrato de forodesina (BCX-1777) (BCX-1777 clorhidrato) es un inhibidor de la fosforilasa (PNP) de nucleÓsido de purina muy potente y activo por vÍa oral con valores de IC50 que oscilan entre 0,48 y 1,57 nM para PNP de humanos, ratones, ratas, monos y perros. El clorhidrato de forodesina (BCX-1777) es un potente inhibidor de la proliferaciÓn de linfocitos humanos. El clorhidrato de forodesina (BCX-1777) podrÍa inducir la apoptosis en células leucémicas al aumentar los niveles de dGTP.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 284490-13-7
Sample solution is provided at 25 µL, 10mM.
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Forodesine hydrochloride is a potent and oral purine nucleoside phosphorylase (PNP) inhibitor with IC50s ranging from 0.48 to 1.57 nM.
[1]. Homminga I, et al. In vitro efficacy of forodesine and nelarabine (ara-G) in pediatric leukemia. Blood. 2011 Aug 25;118(8):2184-90. [2]. Ogura M, et al. Phase I study of BCX1777 (forodesine) in patients with relapsed or refractory peripheral T/natural killer-cell malignancies. Cancer Sci. 2012 Jul;103(7):1290-5. [3]. Bieghs L, et al. The effects of forodesine in murine and human multiple myeloma cells. Adv Hematol. 2010;2010:131895. [4]. Yamauchi T, et al. A nelarabine-resistant T-lymphoblastic leukemia CCRF-CEM variant cell line is cross-resistant to the purine nucleoside phosphorylase inhibitor forodesine. Anticancer Res. 2014 Sep;34(9):4885-92.
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