Ganoderic Acid D |
| Catalog No.GC40900 |
El Ácido ganodérico D, un triterpenoide tetracÍclico altamente oxigenado, es el principal componente activo de Ganoderma lucidum. El Ácido ganodérico D regula positivamente la expresiÓn proteica de SIRT3 e induce la ciclofilina D desacetilada (CypD) por SIRT3. El Ácido ganodérico D inhibe la reprogramaciÓn energética de las células de cÁncer de colon, incluida la absorciÓn de glucosa, la producciÓn de lactato, la producciÓn de piruvato y acetil-coenzima en las células de cÁncer de colon. El Ácido ganodérico D induce la apoptosis del carcinoma cervical humano HeLa.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 108340-60-9
Sample solution is provided at 25 µL, 10mM.
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Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells[1].
Ganoderic acid D can inhibit the growth of numerous cancer cell lines and it inhibits HeLa human cervical carcinoma cells with an IC50 of 17.3 mM[2].
References:
[1]. Liu Z, et al. Effect of ganoderic acid D on colon cancer Warburg effect: Role of SIRT3/cyclophilin D. Eur J Pharmacol. 2018 Apr 5;824:72-77.
[2]. Yue QX,et al. Proteomics characterization of the cytotoxicity mechanism of ganoderic acid D and computer-automated estimation of the possible drug target network. Mol Cell Proteomics. 2008 May;7(5):949-61.
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