Tyrphostin 9 (Synonyms: GCP 5126, Malonoben, NSC 242557, RG50872, SF 6847, Tyrphostin 9, Tyrphostin AG17) |
| Catalog No.GC10758 |
Tyrphostin 9, un inhibidor de PDGFR, es un potente inductor de la fisiÓn mitocondrial.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 10537-47-0
Sample solution is provided at 25 µL, 10mM.
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Tyrphostin 9 is an inhibitor of PDGFR with IC50 value of ~2.5μM [1].
Tyrphostin 9 is generated as specific inhibitor of PDGFR in 1991. It also has inhibitory effect on the proliferation of SMC. Tyrphostin 9 potently inhibits the PDGF-dependent SMC proliferation with IC50 value of 40nM and inhibits the PDGF-dependent autophosphorylation of PDGFR with IC50 value of ~2.5μM. Besides that, Tyrphostin 9 also affects the phosphorylation of PLCγ (IC50 value of about 2.5μM) and the PDGF-dependent c-fos expression. Moreover, Tyrphostin 9 is found to be an inhibitor of EGFR with IC50 value of 460μM [1, 2].
In the rat carotid artery injury model, treatment of Tyrphostin 9 significantly reduces neointimal hyperplasia through inhibiting the tyrosine phosphorylation in injured arteries [1].
References:
[1] Levitzki A. PDGF receptor kinase inhibitors for the treatment of restenosis. Cardiovascular research, 2005, 65(3): 581-586.
[2] Levitzki A. Tyrphostins—potential antiproliferative agents and novel molecular tools. Biochemical pharmacology, 1990, 40(5): 913-918.
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