Concanavalin A |
| Catalog No.GC18572 |
La concanamicina A pertenece a las concanamicinas, una familia de antibióticos macrólidos aislados de Streptomyces diastatochromogenes que son inhibidores altamente activos y selectivos de la vacuolar proton-ATPasa (v-[H+] ATPasa).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 11028-71-0
Sample solution is provided at 25 µL, 10mM.
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Concanamycin A belongs to the concanamycins, a family of macrolide antibiotics isolated from Streptomyces diastatochromogenes that are highly active and selective inhibitors of the vacuolar proton-ATPase (v-[H[+]]ATPase). Among them, concanamycin A is the most selective and potent inhibitor of the V-[H[+]]ATPase.[1]
n vitro study indicated that concanamycin A was active at 5 nM and completely blocked influenza virus infection at 10 nM in MDCK cells. Results showed that concanamycin A blocked viral replication by inhibiting the v-[H[+]]ATPase, thus preventing acidification of endosomes and release of virions into the cytoplasm. An early event in virus infection is the target of concanamytin A. In addition, the inhibition of the v-[H[+]]ATPase by concanamycin A prevents endosomal acidification, inhibiting virus release from endosomes.[1]
References:
[1].Rosario G. et al. Concanamycin A blocks influenza virus entry into cells under acidic conditions. FEBS Letters 1994 June; 349; 327-330.
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