GLPBio

lirucitinib

Catalog No.: GC83422Purity:>98.50%
COASDSData Sheet
lirucitinib is a JAK inhibitor, and has antiinflammatory activity.

Los productos son exclusivamente para uso en investigación. No aptos para uso humano. No vendemos a pacientes.

lirucitinib
Cas No.: 2458115-78-9
10mM (in 1mL DMSO)In Stock
$784.00
1
1mgIn Stock
$284.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citas (Citations)

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    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6739) (2025)
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    Science
    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

Descripción (Description)

lirucitinib is a JAK inhibitor, and has antiinflammatory activity. lirucitinib inhibits various itch- and inflammation-inducing cytokines that depend on JAK1 enzyme activity, as well as allergy-related cytokines. lirucitinib can be used for the study of pruritic skin diseases [1]

In Vitro, Lirucitinib exerts its therapeutic effect by selectively inhibiting JAK1. By blocking the activity of JAK1, Lirucitinib disrupts the downstream signaling of various pro-inflammatory and pruritogenic (itch-inducing) cytokines that are dependent on this enzyme.

References:
[1]. WHO Drug Information, Vol. 38, No. 4, 2024.

Documentos del producto (Product Documents)

Purity:>98.50%Appearance:A solid
COASDSData Sheet

Propiedades químicas (Chemical Properties)

N.º CAS
2458115-78-9
Fórmula molecular
C16H25N5OS
Peso molecular
335.47
Solubilidad
DMSO: 200 mg/mL (596.18 mM; Need ultrasonic)
Almacenamiento
Store at -20°C
Condiciones de envío
Las muestras de evaluación se envían con acumuladores de frío. Los demás tamaños se envían a temperatura ambiente o, previa solicitud, con acumuladores de frío.

Calculadoras (Calculators)Molaridad / Dilución / Peso molecular / Conversión de unidades / Formulación in vivo / Solubilidad

g/mol

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