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Proteasome

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The proteasome is a large multisubunit complex of approximately 2.5 MDa that mediates a wide range of physiological and pathological cellular processes by selectively degrading unnecessary proteins in eukaryotes. The structure of a proteasome is comprised of the catalytic core particle (CP) and two terminal regulatory particles (RPs). The CP (also known as the 20S proteasome) is a barrel shaped multisubunit complex (approximately 750 kDa) consisting of four axially stacked heptameric rings (two outer α-rings and two inner β-rings) with 7 subunits in each ring, where three β subunits (β1, β2 and β5) contain catalytically active threonine residues and are associated with caspase-like, trypsin-like and chymotrypsin-like activities respectively.

Products Related to Proteasome(77)

  • GC12003 structure
    GC12003VR23
    CAS: 1624602-30-7
    Purity: >99.00%

    VR23 es una molécula pequeÑa que inhibe potentemente las actividades de los proteasomas similares a la tripsina (IC50 = 1 nM), los proteosomas similares a la quimotripsina (IC50 = 50-100 nM) y los proteosomas similares a la caspasa (IC50 = 3 μM).

  • GC15802 structure
    GC15802PI-1840
    CAS: 1401223-22-0
    Purity: >99.00%

    PI-1840 es un inhibidor potente y selectivo similar a la quimotripsina (CT-L) con un valor IC50 de 27 nM. PI-1840 inhibe la proliferaciÓn celular y detiene el ciclo celular en la fase G2/M. PI-1840 induce apoptosis e induce autofagia. PI-1840 induce la acumulaciÓn de sustratos de proteasoma p27, Bax e IκB-α.

  • GA20483 structure
    GA20483Ac-Arg-Leu-Arg-AMC
    CAS: 929903-87-7
    Purity: >98%

    Ac-Arg-Leu-Arg-AMC is a fluorescent peptide substrate (excitation/emission wavelength=380/440-460nm) used to detect the trypsin-like activity of the 26S proteasome.

  • GC10102 structure
    GC10102Aclacinomycin A
    CAS: 57576-44-0
    Purity: ≥95%

    An anthracycline with antibiotic and anticancer activities

  • GC10178 structure
    GC10178MG-115
    CAS: 133407-86-0
    Purity: >98.00%

    MG-115 es un potente inhibidor con Kis de 21 nM y 35 nM para el proteasoma 20S y 26S,respectivamnete.

  • GC10342 structure
    GC10342Calpeptin
    CAS: 117591-20-5
    Purity: >98.00%

    Calpeptin es un inhibidor de la cisteína catepsina reversible y permeable a las células. Los valores ID 50 de Calpeptin para calpain I y II (porcine), papaína y calpain I plaquetaria son 52nM, 34nM, 138nM y 20nM, respectivamente. Calpeptin alivia la apoptosis y los cambios inflamatorios secundarios en las células musculares

  • GC10383 structure
    GC10383MG-132
    CAS: 133407-82-6
    Purity: >98.00%

    MG-132 es un inhibidor del proteasoma potente, reversible y permeable a las células.

  • GC10486 structure
    GC10486Salinosporamide A (NPI-0052, Marizomib)
    CAS: 437742-34-2
    Purity: >98.00%

    Salinosporamide A (NPI-0052, Marizomib) es un inhibidor del proteasoma 20S aislado de la actinobacteria marina obligada Salinispora tropica, que muestra una potente actividad antitumoral con un valor IC 50 de 1.3nM

  • GC10561 structure
    GC10561PD 151746
    CAS: 179461-52-0
    Purity: >98%

    PD151746 es un inhibidor de calpaÍna, muestra una selectividad de 20 veces para u-calpaÍna (Ki = 0,26 ± 0,03 μM) sobre m-calpaÍna (Ki = 5,33 ± 0,77 μM).

  • GC11640 structure
    GC11640MDL 28170
    CAS: 88191-84-8
    Purity: >97.00%

    MDL 28170, un inhibidor de aldehído peptídico permeable a las células, reversible y de la calpaína (K i = 0.01μM; K i para la catepsina B = 0.025μM)

  • GC11974 structure
    GC11974Pepstatin A
    CAS: 26305-03-3
    Purity: >98.50%

    Pepstatin A es un inhibidor oralmente activo de las proteasas aspárticas, que es producido por actinomicetos.

  • GC12272 structure
    GC12272CEP-18770
    CAS: 847499-27-8
    Purity: >98.00%

    An inhibitor of chymotrypsin-like proteasome activity

  • GC12494 structure
    GC12494Epoxomicin
    CAS: 134381-21-8
    Purity: >98.50%

    Epoxomicin es un inhibidor selectivo del proteasoma que inhibe eficazmente la actividad similar a la quimotripsina (CH-L) del proteasoma 20S,con un IC 50 de aproximadamente 40-80nM.

  • GC12527 structure
    GC12527MG-101 (Calpain Inhibitor I, ALLN)
    CAS: 110044-82-1
    Purity: >98.00%

    MG-101 (Calpain Inhibitor I, ALLN) también conocido como Calpain Inhibitor I, inhibe selectivamente varias proteasas de cisteína, incluyendo calpain I, calpain II, cathepsin B, y cathepsin L. Los valores de Ki correspondientes para estas enzimas son 90pM, 220pM, 150pM y 500pM

  • GC12784 structure
    GC12784Artemether (SM-224)
    CAS: 71963-77-4
    Purity: >98.00%

    An antiparasitic compound

  • GC13123 structure
    GC13123Lactacystin (Synthetic)
    CAS: 133343-34-7
    Purity: >95.00%

    Un inhibidor selectivo del proteasoma 20S.

  • GC13711 structure
    GC13711Gabexate mesylate
    CAS: 56974-61-9
    Purity: >98.00%

    A serine protease inhibitor

  • GC13718 structure
    GC13718MLN9708
    CAS: 1201902-80-8
    Purity: >98.00%

    A prodrug form of MLN2238

  • GC13789 structure
    GC13789AM 114
    CAS: 856849-35-9
    Purity: >98.50%
  • GC13865 structure
    GC13865PSI
    CAS: 158442-41-2
    Purity: >98%
  • GC15083 structure
    GC15083Celastrol
    CAS: 34157-83-0
    Purity: >99.50%

    Celastrol es un inhibidor del proteasoma con una inhibición potente y preferida del proteasoma 20S purificado con un IC50 de 2.5 μM.

  • GC15089 structure
    GC15089Carfilzomib (PR-171)
    CAS: 868540-17-4
    Purity: >99.00%

    Carfilzomib (PR-171) is a next-generation tetrapeptide epoxyketone proteasome inhibitor (IC 50 =5nM).

  • GC15447 structure
    GC15447Oprozomib (ONX-0912)
    CAS: 935888-69-0
    Purity: >99.50%

    An orally available proteasome inhibitor

  • GC15517 structure
    GC15517MG-262
    CAS: 179324-22-2
    Purity: >98%

    A proteasome inhibitor with diverse biological activities