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ADC Cytotoxin

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ADC Cytotoxin are a large collection of toxins for antibody-drug conjugate (ADC) development projects. The toxins that can be used as payloads should be soluble, amenable to conjugation, and stable. There are myriads of cellular toxins in natural or synthesized, but only a few have been found adaptable for an ADC concept.

The toxins targeting tubulin filaments include Maytansinoids, Auristatins, Taxol derivatives, etc. Amatoxins are a class of transcription-inhibiting agents. They bind to RNA polymerase II, leading to cell apoptosis. Protein toxins function in the similar MOA (mechanism of action) with cellular toxins, they could inhibit protein synthesis and induce cell death. While enzyme-based ADCs alter the microenvironment of disease tissues to disturb their functions.

Products Related to ADC Cytotoxin(111)

  • GC73858 structure
    GC73858Glucocorticoid receptor agonist-4
    CAS: 2842165-72-2
    Purity: >99.00%

    Glucocorticoid receptor agonist-4 (preparado compuesto 5) es un agonista del receptor glucocorticoide que puede ser conjucon anticuerpos TNF-α para el estudio de enfermedades autoinmune inflam.

  • GC73938 structure
    GC73938PBD-monoamide
    CAS: 2093165-00-3
    Purity: >96.00%

    PBD-monoamide, un dímero PBD modificado (pirrolobenzodiazepina), es una citotoxina ADC.

  • GC74118 structure
    GC74118SJG-136 intermediate-1
    CAS: 232931-64-5
    Purity: >99.00%

    SJG-136 intermediate-1 (compuesto 19) es un intermedio para la síntesis SJG-136.

  • GC74122 structure
    GC74122Taltobulin intermediate-4
    CAS: 187345-37-5
    Purity: >99.00%

    Taltobulin intermediate-4 es un intermediario en la síntesis de taltobulina.

  • GC74127 structure
    GC74127(R)-Exatecan Intermediate 1
    CAS: 110351-91-2
    Purity: >99.00%

    (R)-Exatecan Intermediate 1 es un isómero del Exatecan intermediario 1.

  • GC74132 structure
    GC74132Exatecan Intermediate 5
    CAS: 143655-70-3
    Purity: >99.00%

    Exatecan Intermediate 5 es el intermediario de Exatecan y Exatecan (DX-8951) es un inhibide la topoisomerasa I de ADN con un valor de IC50 de 2,2 μM (0,975 μg/mL) que puede usarse en la investigación del cáncer.

  • GC74134 structure
    GC74134Exatecan Intermediate 6
    CAS: 143655-58-7
    Purity: >98.00%

    Exatecan Intermediate 6 es el intermediario de Exatecan y Exatecan (DX-8951) es un inhibide la topoisomerasa I de ADN con un valor de IC50 de 2,2 μM (0,975 μg/mL) que puede usarse en la investigación del cáncer.

  • GC74135 structure
    GC74135Exatecan Intermediate 7
    CAS: 182182-32-7
    Purity: >99.00%

    Exatecan Intermediate 7 es el intermediario de Exatecan y Exatecan (DX-8951) es un inhibide la topoisomerasa I de ADN con un valor de IC50 de 2,2 μM (0,975 μg/mL) que puede usarse en la investigación del cáncer.

  • GC74147 structure
    GC74147TAM558 intermediate-5
    CAS: 1415659-15-2
    Purity: >95.00%

    TAM558 intermediate-5 es un intermediario en la síntesis de TAM558.

  • GC74150 structure
    GC74150Exatecan analog 36
    Purity: >98.00%

    Exatecan analog 36 es un análogo de Exatecan.

  • GC74178 structure
    GC74178Ac-Exatecan
    CAS: 2922852-48-8
    Purity: >98.00%

    Ac-Exatecan es acetilexatecan.

  • GC74652 structure
    GC74652Exatecan Intermediate 2 hydrochloride
    CAS: 2437603-23-9
    Purity: >99.00%

    Exatecan Intermediate 2 hydrochloride (compuesto B) es un intermediario del exatecano (DX-8951,).

  • GC74653 structure
    GC74653Exatecan Intermediate 4
    CAS: 2436720-50-0

    Exatecan Intermediate 4 (compuesto B) es un intermediario del exatecano (DX-8951,).

  • GC74654 structure
    GC74654Exatecan Intermediate 4 dihydrochloride
    Purity: >99.00%

    Exatecan Intermediate 4 dihydrochloride es un intermedio de Exatecan (DX-8951,).

  • GN10449 structure
    GN10449SN-38 (NK012)
    CAS: 86639-52-3
    Purity: >99.50%