GLPBio

Complement System

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The complement system helps or “complements” the ability of antibodies and phagocytic cells to clear pathogens from an organism. It is part of the immune system called the innate immune system that is not adaptable and does not change over the course of an individual's lifetime. The complement system consists of a number of small proteins found in the blood, in general synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex. Over 30 proteins and protein fragments make up the complement system. Three biochemical pathways activate the complement system: the classical complement pathway, the alternative complement pathway, and the lectin pathway.

Products Related to Complement System(69)

  • GC72326 structure
    GC72326Riliprubart
    CAS: 2756228-76-7
    Purity: >99.00%

    Riliprubart (SAR445088) es un anticuerpo monoclonal humanianti-c1s que inhic1s activado en la porción proximal del sistema de complemento clásico.

  • GC72354 structure
    GC72354Lampalizumab
    CAS: 1278466-20-8
    Purity: >99.00%

    Lampalizumab (RG 7417) es un anticuerpo monoclonal humanidirigido al Factor de complemento D en la vía alternativa del complemento.

  • GC72391 structure
    GC72391Avdoralimab
    CAS: 2226393-85-5
    Purity: >95.00%

    Avdoralimab (IPH 5401) es un anticuerpo monoclonal IgGκ totalmente humano que se dirige al receptor 1 del complemento C5a (C5aR1) que impide su Unión al C5a.

  • GC72473 structure
    GC72473Crovalimab
    CAS: 1917321-26-6
    Purity: >98.00%

    Crovalimab (SKY59; RO7112689) es un nuevo anticuerpo humanicontra C5 de una manera dependiente del pH con KDs de 15.2 nM y 16.8 μM a pH 7.4 y 5.8, respectivamente.

  • GC73106 structure
    GC73106Cemdisiran sodium
    Purity: >96.00%

    Cemdisiran sodium es una n-acetilgalactosamina (GalNAc) siRNA conjugpara la investigación de enfermedades mediadas por el complemento mediante la supresión de la producción hepática de complemento 5 (C5) proteína.

  • GC73413 structure
    GC73413ARC186 sodium
    Purity: >94.00%

    ARC186 sodium es un aptámero no conjude de 40KDa PEG con una secuencia idéntica a 0 Avacincaptad pegol ARC1905 sódico.

  • GC74045 structure
    GC74045Zoracopan
    CAS: 2243483-63-6
    Purity: >99.00%

    Zoracopan es un inhibidor selectivo del factor de complemento D (CFD).

  • GC74354 structure
    GC74354Pegcetacoplan acetate
    Purity: >98.00%

    Pegcetacoplan acetate es un péptido inhibidor del complemento C3 pegilado.

  • GC74552 structure
    GC74552Gefurulimab
    CAS: 2456407-94-4
    Purity: >97.00%

    Gefurulimab (ALXN-1720) es un anticuerpo biespecífico derivado del humano contra el complemento C5 y la albúmina que se une a C5 y bloquea su activación.

  • GC74590 structure
    GC74590Pozelimab
    CAS: 2096328-94-6
    Purity: >99.00%

    Pozelimab (REGN3918) es un anticuerpo monoclonal IgG4 anti-C5 totalmente humano.

  • GC79355 structure
    GC79355SAR-443809
    Purity: >97.00%

    SAR-443809 is a monoclonal antibody targeting complement factor Bb that inhibits the alternative complement pathway.

  • GC79356 structure
    GC79356Ascuprubart
    CAS: 3056020-15-3
    Purity: >97.50%

    Ascuprubart is an anti-human monoclonal antibody targeting Complement C5.

  • GC79357 structure
    GC79357ANX-M1 (Human IgG1)
    Purity: >99.00%

    ANX-M1 is a blood-brain barrier-permeable anti- C1q antibody.

  • GC79358 structure
    GC79358Lexucitug
    CAS: 3058391-51-5
    Purity: >98.00%

    Lexucitug (DCSZ-11) is a humanized monoclonal antibody targeting CD93.

  • GC79359 structure
    GC79359RPARPAR acetate
    Purity: >99.00%

    RPARPAR acetate is a CendR tumor-penetrating peptide.

  • GC79360 structure
    GC79360Pulchinenoside J
    CAS: 1476801-10-1
    Purity: >98%

    Pulchinenoside J is a lupane-type triterpenoid saponin and a complement system inhibitor that acts via the classical pathway.

  • GC79361 structure
    GC79361Vonaprument
    CAS: 3050549-24-8
    Purity: >98%

    Vonaprument (ANX-007) is an intravitreally injected C1q antibody fragment (with a molecular weight of approximately 48 kDa) and a human monoclonal antibody.

  • GC79362 structure
    GC79362Anti-CD55 Antibody
    Purity: >99.50%

    Anti-CD55 Antibody is an anti- CD55 antibody.

  • GC79418 structure
    GC79418NRPa-308
    CAS: 717863-53-1
    Purity: >98.50%

    NRPa-308 is a potent and orally active Neuropilin-1 (NRP-1) antagonist with an IC 50 of 42 μM for inhibiting VEGF-A 165 binding to NRP-1.

  • GC81483 structure
    GC81483AKIR001
    Purity: >99.00%

    AKIR001 is a high-affinity human IgG1 antibody targeting CD44v6.

  • GF10303 structure
    GF10303Lipoteichoic acid
    CAS: 56411-57-5

    Lipoteichoic acid es un ácido teicoico que se localiza en la pared celular de las bacterias grampositivas y participa en la activación de respuestas inmunológicas y vías de señalización celular