FTY720 phenoxy-biotin |
| Catalog No.GC43701 |
FTY720 es un modulador inmunológico que regula a la baja los receptores de esfingosina-1-fosfato (S1P), mejora la actividad del transportador de esfingosina ABCB1 y el transportador de leucotrienos C4 ABCC1 e inhibe la actividad de fosfolipasa A2 citosólica.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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FTY720 is an immune modulator that down-regulates sphingosine-1-phosphate (S1P) receptors, enhances the activity of the sphingosine transporter ABCB1 and the leukotriene C4 transporter ABCC1 and inhibits cytosolic phospholipase A2 activity. It is known that some of the effects of FTY720 require its phosphorylation by sphingosine kinases in vivo, with FTY720-phosphate binding to and down-regulating S1P receptors. Biotin-FTY720 is a biotin-tagged analog of FTY720. The hydroxy methyl side chain of FTY720 that is targeted for phosphorylation by sphingosine kinases is retained in this analog, suggesting that it would likewise be phosphorylated in vivo.
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