Thalidomide-propargyl |
| Catalog No.GC38862 |
La talidomida-propargilo es el ligando Cereblon basado en la talidomida que se utiliza en el reclutamiento de la proteÍna CRBN. La talidomida-propargilo se puede conectar al ligando de la proteÍna mediante un conector para formar los PROTAC que contienen IMiD.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2098487-39-7
Sample solution is provided at 25 µL, 10mM.
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Thalidomide-propargyl is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-propargyl can be connected to the ligand for protein by a linker to form the IMiD containing PROTACs[1].
[1]. Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461.
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