GLPBio

SR 3576

Catalog No.: GC16652Purity:>98%
COASDSData Sheet

JNK3 inhibitor, potent and selective

Products are for research use only. Not for human use. We do not sell to patients.

SR 3576
Cas No.: 1164153-22-3
10mgIn Stock
$287.00
1
50mgIn Stock
$1,205.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

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    610, 366–372 (2022)
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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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Description

SR-3576 is a cell-permeable, potent and selective JNK3 (c-Jun N-terminal kinase 3) inhibitor.

SR-3576 is a small molecule inhibitor belonging to aminopyrazole class that selectively inhibits JNK3 with >2800 fold selectively over p38.

Protocol

Cell experiment[1]:

Cell lines

Human ovarian cancer cisplatin-resistant SKOV3/DDP cells

Preparation method

The solubility of this compound in DMSO is > 10 mM. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

24 h, 2 μM

Applications

SR 3576 is a specific inhibitor of JNK3. Inhibition of JNK3 by SR 3576 exacerbates oxidative stress and suppresses autophagic flux, resulting in an increase of apoptosis induced by S1 in human ovarian cancer SKOV3/DDP cells.

References:

[1]. Yang X, Xiang X, Xia M, et al. Inhibition of JNK3 promotes apoptosis induced by BH3 mimetic S1 in chemoresistant human ovarian cancer cells[J]. The Anatomical Record, 2015, 298(2): 386-395.

Chemical Properties

CAS No.
1164153-22-3
Chemical Name
3-(4-(3-(m-tolyl)ureido)-1H-pyrazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide
SMILES
O=C(C1=CC(N2N=CC(NC(NC3=CC=CC(C)=C3)=O)=C2)=CC=C1)NC(C=C4OC)=CC(OC)=C4OC
Molecular Formula
C27H27N5O5
Molecular Weight
501.53
Solubility
<50.15mg/ml in DMSO
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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