JNK

JNK/c-Jun interaction inhibitor

Ac-muramyl-Ala-D-Glu-NH₂ (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln.

AS601245 is a potent ATP-competitive JNK inhibitor with IC 50 values of 0.15µM, 0.22, and 0.07µM for JNK1, JNK2, and JNK3, respectively.

A potent JNK inhibitor

A signal-specific JNK/p38 pathway and TAK 1 inhibitor

JNK inhibitor

Anisomycin, an antibiotic isolated from Streptomyces griseus, is also a JNK activator.

JNK inhibitor

A selective, orally bioavailable JNK inhibitor

inhibitor of GADD45β/MKK7 complex

Peptide inhibitor of c-Jun N-terminal kinase (JNK)

JNK-IN-8 is the first irreversible JNK inhibitor that acts on JNK1, JNK2, and JNK3 with high specificity, with IC 50 values of 4.7 nM, 18.7 nM, and 1 nM in the A375 cell line, respectively.

A potent inhibitor of JNK1

A potent, specific pan-JNK inhibitor

Novel Janus kinase inhibitor

A non-selective JNK inhibitor

JNK3 inhibitor, potent and selective

TCS JNK 6o (TCS JNK 6o) is a c-Jun N-terminal kinases (JNK-1, -2, and -3) inhibitor with Ki values of 2 nM, 4 nM, 52 nM, respectively, and has IC50 values of 45 nM and 160 nM for JNK-1 and -2, respectively.

Guggulsterone is a plant sterol extracted from the resin of the plant Commiphora wightii. Guggulsterone can inhibit the growth of a wide variety of tumor cells and induce apoptosis through downregulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP, and survivin), modulation of cell cycle proteins (such as Cyclin D1 and c-Myc), activation of caspases, inhibition of Akt, and activation of JNK.

Ginsenoside CK, a secondary ginsenoside biotransformed from major ginsenosides, is more bioavailable and soluble than its parent ginsenosides and holds great significance.

IMM-H007, an adenosine derivative, is an activator of AMP-Activated Protein Kinase (AMPK). IMM-H007 is a potential drug for treating cardiac dysfunction. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 (ATP binding cassette subfamily a member 1) degradation and facilitates its cell-surface localization in macrophages, thereby promotes cholesterol efflux.

Tanzisertib (CC-930, JNK-930, JNKI-1) is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively.

D-JNKI-1 (AM-111) (AM-111) is a highly potent and cell-permeable peptide inhibitor of JNK.

SR-3306 is a selective, potent, highly brain penetrant JNK inhibitor.