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Thymidylate Synthase

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Thymidylate synthase (TS) is an enzyme catalyzing the sole de novo pathway for the biosynthesis of deoxythymidine monophosphate (dTMP) in which deoxyuridine monophosphate (dUMP) is reductively methylated by 5,10-methylenetetrahydrofolate (CH2H4folate) with the generation of dTMP and dihydrofolate (H2folate). TS has been found in a wide range of sources, including bacteria, bacteriophage, yeast, viruses and vertebrates, where it is usually a dimer consisting of identical subunits (30 to 35 kDa each). However, protozoal TS is a bifunctional protein with dihydrofolate reductase (DHFR) on the same polypeptide chain, where TS and DHFR domains are located on the carboxy terminus and amino terminus respectively.

Products Related to Thymidylate Synthase(10)

  • GC11099 structure
    GC11099Doxifluridine
    CAS: 3094-09-5
    Purity: >99.50%

    oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU)

  • GC13803 structure
    GC13803Trifluridine
    CAS: 70-00-8
    Purity: >99.50%

    Triflurdine (Viroptic) (Trifluorothymidine; 5-Trifluorothymidine; TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Triflurdine (Viroptic) is an antiviral drug for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity.

  • GC11610 structure
    GC11610Pemetrexed
    CAS: 150399-23-8
    Purity: >99.00%

    Pemetrexed (also known as pemetrexed disodium) is a novel antifolate antimetabolite targeting multiple enzymes involved in both pyrimidine and purine synthesis.

  • GC14681 structure
    GC14681Nolatrexed (AG-337)
    CAS: 152946-68-4
    Purity: >98.50%

    Nolatrexed (AG-337) (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase. Nolatrexed (AG-337) (AG 337) induces cell cycle arrest in S phase of cancer cells. Anti-cancer activity.

  • GC17694 structure
    GC17694Pemetrexed disodium hemipenta hydrate
    CAS: 357166-30-4
    Purity: >99.00%
  • GC17750 structure
    GC17750Raltitrexed
    CAS: 112887-68-0
    Purity: >98.00%

    Thymidylate synthase inhibitor

  • GC19348 structure
    GC19348TAS-102
    CAS: 733030-01-8
    Purity: >98.00%

    TAS-102 (TAS-102) is a potent and orally active nucleoside antitumor agent. The composition of TAS-102 (TAS-102) is a 1:0.5 mixture (on a molar basis) of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI). TAS-102 (TAS-102) shows the antitumor activity mainly via the inhibition of thymidylate synthase (TS) and incorporation into DNA.

  • GC37798 structure
    GC37798Tipiracil
    CAS: 183204-74-2
    Purity: >98%

    Tipiracil is a competitive inhibitor of thymidine phosphorylase (TPase), with an apparent Ki value of 17nM against recombinant human TPase.

  • GC62645 structure
    GC62645Fosifloxuridine nafalbenamide
    CAS: 1332837-31-6
    Purity: >98.00%

    Fosifloxuridine nafalbenamide (NUC-3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor. Fosifloxuridine nafalbenamide has anticancer activity. Fosifloxuridine nafalbenamide has the potential to evoke a host immune response and enhance immunotherapy.

  • GC64726 structure
    GC6472610-Formyl-5,8-dideazafolic acid
    CAS: 61038-31-1
    Purity: >96.00%

    10-Formyl-5,8-dideazafolic acid is a thymidylate synthase inhibitor.