TRPM8 antagonist WS-3 is an agonist of TRPM8 with an EC50 of 3.7 μM. EC50: 3.7 μM (TRPM8)[1]
[1]. Behrendt HJ, et al. Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol. 2004 Feb;141(4):737-45.
















