Tumor Microenvironment

An irreversible inhibitor of thioredoxin-1

Cardanol monoene is a phenol found in cashew nut shell liquid that reversibly inhibits tyrosinase with an IC50 value of 56 uM in vitro.

(±)-Dunnione is a naturally occurring naphthoquinone with diverse biological activities.

Tiopronin is an antioxidant that has diverse biological activities.

2,3-Dimethoxy-5-methyl-p-benzoquinone (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea.

In addition to its role in the Krebs cycle, α-ketoglutarate (2-oxoglutarate) has roles as a substrate or modulator of enzymes.

Terrecyclic acid is a sesquiterpene originally isolated from A.

PRLX-93936 is an analog of erastin that has antitumor activity.

9(E),11(E),13(E)-Octadecatrienoic acid (β-ESA) is a conjugated polyunsaturated fatty acid that is found in plant seed oils and in mixtures of conjugated linolenic acids synthesized by the alkaline isomerization of linolenic acid.

Jacaric acid is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacaranda plants.

CAY10730 is a turn-on fluorescent probe for the detection of nitroreductase activity, a marker of hypoxia.

Cytostatin is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 μg/ml, respectively) and B16 cells metastatic activity in mice.

Doxorubicinol is the major metabolite of doxorubicin, an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks.

Ganglioside GD1a is a sialic acid-containing glycosphingolipid found in brain, erythrocytes, bone marrow, testis, spleen, and liver.

An internal standard for the quantification of rhein

A diarylnonanoid with diverse biological activities

An amine-reactive fluorescent probe

EP4 receptor antagonist 1 is a potent and selective antagonist of the prostaglandin E2 receptor EP4 subtype. EP4 receptor antagonist 1 exhibits half-maximal inhibitory concentration (IC₅₀) values of 6.1nM and 16.2nM for human and mouse EP4 receptors.

An internal standard for the quantification of pomalidomide

A mixture of N-glycolyl-ganglioside G M3

PCI 45227 (PCI-45227) is a dihydrodiolactive metabolite of Ibrutinib, has inhibitory activity towards BTK approximately 15 times lower than that of ibrutinib.

A glucose derivative with anticancer activity

A synthetic cationic amphiphilic peptide