PRLX-93936 |
| Catalog No.GC41572 |
PRLX-93936 is an analog of erastin that has antitumor activity.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 903499-49-0
Sample solution is provided at 25 µL, 10mM.
PRLX-93936 is an analog of erastin that has antitumor activity. It inhibits the hypoxia-inducible factor 1 (HIF-1) signaling pathway under hypoxic conditions (IC50 = 0.09 μM in a cell-based reporter assay). PRLX-93936 (1 μM) also inhibits hypoxia-induced increases in HIF-1α expression in ME-180 cervical cancer cells. It inhibits the growth of HT-1080 fibrosarcoma, OVCAR-5 ovarian cancer, BJELR tumorigenic primary fibroblast, and PANC-1 pancreatic cancer cells with IC50 values of less than 100 nM. PRLX-93936 inhibits tumor growth in PANC-1 and HT-1080 xenograft models when administered at a dose of 50 mg/kg and induces tumor regression when administered at a dose of 100 mg/kg.
Average Rating: 5 (Based on Reviews and 15 reference(s) in Google Scholar.)
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