Tyramine (Synonyms: 2-(4-Hydroxyphenyl)ethylamine, NSC 249188, p-Tyramine, Uteramine) |
Catalog No.GC31223 |
A monoamine and TAAR1 agonist
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 51-67-2
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Tyramine is an indirectly acting sympathomimetic amine that releases norepinephrine from presynaptic nerve terminals.
Tyramine is an indirectly acting sympathomimetic amine that releases norepinephrine from presynaptic nerve terminals[1]. Tyramine potentiates the postsynaptic inhibitory effects of norepinephrine on the firing of cortical neurones in the rat[2]. Although tyramine exists in three isomerie forms, the orthoisomer and metaisomers are present in very low concentrations and it is the paraisomer that is implied when reference is made to tyramine. The tyramines are generally present in nanogram/gram concentrations in brain tissue, but they have a very rapid turnover. The CNS role of tyramine is unclear, it has been suggested that it is involved in the modulation of dopamine synthesis and may also regulate norepinephrine turnover[3].
[1]. Harrison WM, et al. The tyramine challenge test as a marker for melancholia. Arch Gen Psychiatry. 1984 Jul;41(7):681-5. [2]. BURN JH, et al. The action of sympathomimetic amines in animals treated with reserpine. J Physiol. 1958 Dec 4;144(2):314-36. [3]. Juorio AV, et al. A possible role for tyramines in brain function and some mental disorders. Gen Pharmacol. 1982;13(3):181-3.
Cas No. | 51-67-2 | SDF | |
Synonyms | 2-(4-Hydroxyphenyl)ethylamine, NSC 249188, p-Tyramine, Uteramine | ||
Canonical SMILES | C1=C(C=CC(=C1)O)CCN | ||
Formula | C8H11NO | M.Wt | 137.18 |
Solubility | DMF: 25 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 5 mg/ml | Storage | 4°C, protect from light |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
1 mg | 5 mg | 10 mg | |
1 mM | 7.2897 mL | 36.4485 mL | 72.8969 mL |
5 mM | 1.4579 mL | 7.2897 mL | 14.5794 mL |
10 mM | 0.729 mL | 3.6448 mL | 7.2897 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
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