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Tyramine (Synonyms: 2-(4-Hydroxyphenyl)ethylamine, NSC 249188, p-Tyramine, Uteramine)

Catalog No.GC31223

A monoamine and TAAR1 agonist

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Tyramine Chemical Structure

Cas No.: 51-67-2

Size Price Stock Qty
10mM (in 1mL DMSO)
$35.00
In stock
500mg
$28.00
In stock
1g
$35.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Tyramine is an indirectly acting sympathomimetic amine that releases norepinephrine from presynaptic nerve terminals.

Tyramine is an indirectly acting sympathomimetic amine that releases norepinephrine from presynaptic nerve terminals[1]. Tyramine potentiates the postsynaptic inhibitory effects of norepinephrine on the firing of cortical neurones in the rat[2]. Although tyramine exists in three isomerie forms, the orthoisomer and metaisomers are present in very low concentrations and it is the paraisomer that is implied when reference is made to tyramine. The tyramines are generally present in nanogram/gram concentrations in brain tissue, but they have a very rapid turnover. The CNS role of tyramine is unclear, it has been suggested that it is involved in the modulation of dopamine synthesis and may also regulate norepinephrine turnover[3].

[1]. Harrison WM, et al. The tyramine challenge test as a marker for melancholia. Arch Gen Psychiatry. 1984 Jul;41(7):681-5. [2]. BURN JH, et al. The action of sympathomimetic amines in animals treated with reserpine. J Physiol. 1958 Dec 4;144(2):314-36. [3]. Juorio AV, et al. A possible role for tyramines in brain function and some mental disorders. Gen Pharmacol. 1982;13(3):181-3.

Chemical Properties

Cas No. 51-67-2 SDF
Synonyms 2-(4-Hydroxyphenyl)ethylamine, NSC 249188, p-Tyramine, Uteramine
Canonical SMILES C1=C(C=CC(=C1)O)CCN
Formula C8H11NO M.Wt 137.18
Solubility DMF: 25 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 5 mg/ml Storage 4°C, protect from light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 7.2897 mL 36.4485 mL 72.8969 mL
5 mM 1.4579 mL 7.2897 mL 14.5794 mL
10 mM 0.729 mL 3.6448 mL 7.2897 mL
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