Corn oil |
| Catalog No.GC32712 |
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
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Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
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Animal experiment: |
Rats[1]Male and female F344 rats (50 days of age are individually housed in polycarbonate cages on hardwood bedding in rooms maintained at 24°C with 12 h light/dark cycles. All rats are given unlimited access to distilled water and NIH-07 open formula diet. Orally gavaged animals receive corn oil or distilled water 5 days/week at a volume of 5 mL/kg body wt/day[1]. |
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References: [1]. Hursting SD, et al. Inhibition of rat mononuclear cell leukemia by corn oil gavage: in vivo, in situ and immune competence studies. Carcinogenesis. 1994 Feb;15(2):193-9. |
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Corn oil, extracted from the germ of corn, can be used as a carrier for drug molecules and has anti-tumor activity.
Corn oil-gavaged rats have ~25% lower MNCL incidence as well as longer MNCL latency and increase survival. Corn oil-gavaged rats have 54% lower serum growth hormone (GH) levels, and replacement of GH into corn oil-gavaged rats by osmotic minipump infusion increase in situ MNCL cell proliferation to rates observed in water-gavaged animals. Corn oil-gavaged rats, which receive 5 mL corn oil /kg body wt/day for 5 days/week, have a 3-fold increase in fat intake compared to nongavaged or water-gavaged control rats[1]. Intraperitoneal injection of trace amounts of corn oil prior to and following the injection of 40u201350 mg of tissue from hepatoma 7777 or 7800 into the thigh of adult male Buffalo rats result in a marked decrease in the growth rate of both tumors[2].
[1]. Hursting SD, et al. Inhibition of rat mononuclear cell leukemia by corn oil gavage: in vivo, in situ and immune competence studies. Carcinogenesis. 1994 Feb;15(2):193-9. [2]. Gilbertson JR, et al. Inhibition of growth of Morris hepatomas 7777 and 7800 by corn oil. Oncology. 1977;34(2):62-4.
| Cas No. | 8001-30-7 | SDF | |
| Synonyms | N/A | ||
| Chemical Name | N/A | ||
| Canonical SMILES | [Corn oil] | ||
| Formula | N/A | M.Wt | N/A |
| Solubility | Ethanol: 10 mg/mL | Storage | Store at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
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Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
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