Tyrosinases

mushroom tyrosinase inhibitor

Tyrosinase inhibitor

XMD16-5 is a potent TNK2 inhibitor with IC50 values of 16 and 77 nM for the D163E and R806Q mutations, respectively.

XMD8-87 is a potent TNK2 inhibitor with IC50 values of 38 and 113 nM for the D163E and R806Q mutations, respectively.

Tyrosinase (From mushrooms, ≥1000 units/mg dry weight) is an enzyme that catalyzes the oxidation of phenolic compounds (such as tyrosine, phenolic compounds, etc.) into quinones.

Potassium hydrogen 2-oxoglutarate is located at the intersection of carbon and nitrogen metabolism pathways.

Calcium 2-oxoglutarate (Calcium oxoglurate, Calcium 2-oxopentanedioate, Calcium α-ketoglutarate, Calcium AKG, Calcium 2-ketoglutaric acid, Calcium oxoglutaric acid) is the Calcium salt form of 2-oxoglutarate. 2-oxoglutarate is naturally found in organisms and is a well-known intermediate in the production of ATP or GTP in the Krebs cycle. 2-oxoglutarate is a reversible inhibitor of tyrosinase with IC50 of 15 mM.

2-Ketoglutaric acid is a reversible inhibitor of tyrosinase, with an IC 50 value of 15 ± 0.5mM.

4-Butylresorcinol (Butylresorcinol) is a phenol derivative which can inhibit tyrosinase with IC50 of 11.27 μM.

A phenol with diverse biological activities

Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.

Oxyresveratrol (trans-Oxyresveratrol) (trans-Oxyresveratrol (trans-Oxyresveratrol)) is a potent naturally occurring antioxidant and free radical scavenger (IC50 of 28.9 μM against DPPH free radicals).

Benzoyloxypaeoniflorin, isolated from the root of Paeonia suffruticosa, is a tyrosinase inhibitor against mushroom tyrosinase with IC50 of 0.453 mM.

Chimonanthine is an alkaloid of Chimonanthus praecox, inhibits tyrosinase and tyrosine-related protein-1 mRNA expression, amd inhibits melanogenesis.

Glabrene, an isoflavene derived from licorice root, shows estrogen-like activity.

Kushenol A (Leachianone E) is isolated from the root of Sophora flavescent. Kushenol A is a non-competitive tyrosinase inhibitor to block the conversion of L-tyrosine to L-DOPA, shows IC50 and Kivalues of 1.1 μM and 0.4 μM, respectively. Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase (IC50: 45 μM; Ki: 6.8 μM) and β-amylase. Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging.

Methyl rosmarinate is a noncompetitive tyrosinase inhibitor which is isolated from Rabdosia serra, with an IC50 of 0.28 mM for mushroom tyrosinase, and also inhibits a-glucosidase.

Mulberroside F is one of the main bioactive constituents in mulberry (Morus alba L.

Swertiajaponin is a tyrosinase inhibitor, forms multiple hydrogen bonds and hydrophobic interactions with the binding pocket of tyrosinase, with an IC50 of 43.47 μM.

Trifolirhizin is a pterocarpan flavonoid isolated from the roots of Sophora flavescens.

(R)-Trolox is a vitamin E analogue and a competitive tyrosinase inhibitor with a Ki value of 0.83 mM and a ID50 value of 1.88 mM. The (R)-Trolox has stronger tyrosinase affinity than the (S) enantiomer (Ki value of 0.61 mM).

Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound.

Mirificin (Puerarin apioside) is a isoflavone in Puerariae Lobatae Radix.

3,4-Dimethoxyphenol is a plant-derived phenylpropanoid compound and can use as a whitening agent in cosmetics.