GLPBio

UCB9386

Catalog No.: GC84341Purity:>99.50%
COASDSData Sheet
UCB9386 is the selective and brain penetrant inhibitor for Nuak1 with a pIC 50 of 10.1.

Products are for research use only. Not for human use. We do not sell to patients.

UCB9386
Cas No.: 3096082-93-5
1mgIn Stock
$170.00
1
5mgIn Stock
$425.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

No citations are currently available for this product. Below are selected publications citing GlpBio products.
  • Nature cover
    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
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    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    Cell Research
    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

Description

UCB9386 is the selective and brain penetrant inhibitor for Nuak1 with a pIC 50 of 10.1. UCB9386 inhibits Nuak2 and Kak2 with an inhibition rate of ca. 50% at 10 nM [1].

References:
[1]. Poullennec KG, et al., Discovery of UCB9386: A Potent, Selective, and Brain-Penetrant Nuak1 Inhibitor Suitable for In Vivo Pharmacological Studies. J Med Chem. 2024 Dec 12;67(23):20879-20910.

Product Documents

Purity:>99.50%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
3096082-93-5
Molecular Formula
C27H26N8O
Molecular Weight
478.55
Solubility
DMSO: 83.33 mg/mL (174.13 mM; ultrasonic and adjust pH to 7 with 1 M HCl)
Storage
Store at -20°C
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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