GLPBio

WD6305 TFA

Catalog No.: GC73868Purity:>98.00%
COASDSData Sheet
WD6305 TFA is a potent METTL3-targeted PROTAC degrader.

Products are for research use only. Not for human use. We do not sell to patients.

WD6305 TFA
1 mgIn Stock
$230.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

No citations are currently available for this product. Below are selected publications citing GlpBio products.
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
  • Cell Research cover
    Cell Research
    34, 683–706 (2024)
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    Cell Research
    33, 273–287 (2023)
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    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

Description

WD6305 TFA is a potent METTL3-targeted PROTAC degrader. WD6305 TFA selectively reduces the METTL3 and METTL14 complex. WD6305 TFA inhibits m6A modification and the proliferation of AML cells and promotes apoptosis. WD6305 TFA can be used for the research of leukemic.

References:
[1]. Du W, et al. Discovery of a PROTAC degrader for METTL3-METTL14 complex. Cell Chem Biol. 2024 Jan 2:S2451-9456(23)00439-7

Product Documents

Purity:>98.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

Molecular Formula
C63H76F5N11O7S
Molecular Weight
1226.4
Solubility
DMSO : 95 mg/mL (77.46 mM; Need ultrasonic)
Storage
4°C, sealed storage, away from moisture
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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