GLPBio

Acyltransferase

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DGAT (acyl-CoA: diacylglycerol acyltransferase) is a transmembrane enzyme that acts in the final and committed step of triacylglycerides (TAGs) synthesis, and it has been proposed to be the rate-limiting enzyme in plant storage lipid accumulation. DGAT catalyzes the acylation of sn-1,2-diacylglycerol (DAG) at the sn-3 position using an acyl-CoA substrate. DGAT has been proposed to be the rate-limiting enzyme in plant storage lipid accumulation. DGAT is considered a key enzyme for biotechnological purposes; it might be utilized to increase oil content in oleaginous plant species.

DGAT1 and DGAT2 are two of the enzymes that are responsible for the main part of TAG synthesis in most organisms, and they have been studied in many eukaryotic organisms.

Products Related to Acyltransferase(69)

  • GC14870 structure
    GC14870OSMI-1
    CAS: 1681056-61-0
    Purity: >98.00%

    OSMI-1 is an O-GlcNAc transferase (OGT) small molecule inhibitor that does not significantly affect other glycosyltransferases.

  • GC10999 structure
    GC10999Avasimibe
    CAS: 166518-60-1
    Purity: >98.00%

    Avasimibe is a selective and oral acyl coenzyme A:cholesterol acyltransferase (ACAT) inhibitor (IC 50 =12μmol/L).

  • GC11036 structure
    GC11036LCQ-908
    CAS: 956136-95-1
    Purity: >98.00%
  • GC11475 structure
    GC11475AZD7687
    CAS: 1166827-44-6
    Purity: >99.00%
  • GC12391 structure
    GC12391Xanthohumol
    CAS: 6754-58-1
    Purity: >98.00%

    Xanthohumol is the main prenylflavonoid in hops that inhibits diacylglycerol acyltransferase (DGAT) with IC 50 value of 50.3μM.

  • GC12411 structure
    GC12411RHC 80267
    CAS: 83654-05-1
    Purity: >98.00%

    RHC 80267 is a potent and selective diacylglycerol lipase (DAGL) inhibitor. RHC 80267 can also inhibit cholinesterase activity (IC₅₀= 4μM), suppress cyclooxygenase (COX) activity, and inhibit phosphatidylcholine hydrolysis.

  • GC12604 structure
    GC12604Fumonisin B1
    CAS: 116355-83-0
    Purity: >98.00%

    Fumonisin B1 is a mycotoxin produced from F. moniliforme, a prevalent fungus of corn and other grains.

  • GC15274 structure
    GC15274PF-04620110
    CAS: 1109276-89-2
    Purity: >98.00%

    PF-04620110 is an orally active, selective diacylglycerol acyltransferase-1 (DGAT1) inhibitor (IC 50 = 19nM).

  • GC15614 structure
    GC15614A922500
    CAS: 959122-11-3
    Purity: >98.50%

    A922500 is a potent, selective, and orally bioavailable diacylglycerol acyltransferase 1 (DGAT-1) inhibitor with IC 50 values of 9 and 22nM against human and mouse DGAT-1, respectively.

  • GC16133 structure
    GC16133DGAT-1 inhibitor
    CAS: 701232-20-4
    Purity: >98.00%

    A DGAT-1 inhibitor

  • GC16257 structure
    GC16257AZD 3988
    CAS: 892489-52-0
    Purity: >98.00%

    diacylglycerol acyltransferase (DGAT-1) inhibitor

  • GC16823 structure
    GC16823Enniatin Complex
    CAS: 11113-62-5
    Purity: >98%

    ionophore

  • GC17342 structure
    GC17342Beauvericin
    CAS: 26048-05-5
    Purity: >98.00%

    Beauvericin is a cyclic hexadecanopeptide mycotoxin and a potent inhibitor of acyl-CoA:cholesterol acyltransferase 1 (ACAT1), which is involved in multiple tumor-related pathways.

  • GC17693 structure
    GC17693Enniatin B
    CAS: 917-13-5
    Purity: >98%

    ionophore with some capacity to facilitate import of K+ and Na+ across membranes

  • GC18959 structure
    GC18959PF-06424439
    CAS: 1469284-79-4
    Purity: >98.00%

    PF-06424439 is a highly efficient and orally bioavailable selective diacylglycerol acyltransferase 2 (DGAT2) small molecule inhibitor with an IC 50 value of 14nM.

  • GC18961 structure
    GC18961Pyripyropene A
    CAS: 147444-03-9
    Purity: >95.00%

    Acyl-CoA: cholesterol acyltransferase (ACAT) is a key enzyme for cholesteryl ester accumulation in atherogenesis, lipoprotein formation in liver, and cholesterol absorption from intestines, all of which are events that contribute to the atherosclerotic process.

  • GC30438 structure
    GC30438RP 70676
    CAS: 136609-26-2
    Purity: >99.50%

    RP 70676 is a potent inhibitor of ACAT, with IC50 of 25 and 44 nM for rat and rabbit ACAT.

  • GC31080 structure
    GC31080GOAT-IN-1
    CAS: 1452473-54-9
    Purity: >98.00%

    GOAT-IN-1 is an inhibitor of ghrelin O-acyltransferase (GOAT), which could be useful for the prophylaxis or treatment of obesity, diabetes, hyperlipidemia, metabolic, non-alcoholic fatty liver, steatohepatitis, sarcopenia, appetite control, alcohol/narcotic dependence, Alzheimer’s disease, Parkinson’s disease, cerebrovascular dementia, cerebral apoplexy, cerebral infarction, cardic disease, some kind of tumors.

  • GC31362 structure
    GC31362MGAT2-IN-1
    CAS: 1800025-30-2
    Purity: >99.00%

    MGAT2-IN-1 is an orally active inhibitor of monoacylglycerol acyltransferase (MGAT2) with IC50 of 7.8 and 2.4 nM for human and mouse MGAT2, respectively.

  • GC31375 structure
    GC31375PF-06471553
    CAS: 1808094-07-6
    Purity: >98.00%

    PF-06471553 is a potent, selective and orally available monoacylglycerol acyltransferase 3 (MGAT3) inhibitor, with an IC50 of 92 nM.

  • GC31384 structure
    GC31384FCE 28654
    CAS: 169474-77-5
    Purity: >98%

    FCE 28654 is an inhibitor of acylCoA: cholesterol acyltransferase (ACAT), weakly inhibiting ACAT in microsomes from rabbit aorta and intestine, and monkey liver, with IC50s of 2.55, 1.08 and 5.69 μM, respcetively.

  • GC31443 structure
    GC31443YM17E
    CAS: 124900-72-7
    Purity: >98%

    YM17E is an inhibitor of acyl CoA:cholesterol acyltransferase (ACAT), with IC50 of 44 nM in rabbit liver microsomes in vitro.

  • GC31517 structure
    GC31517OSMI-4
    CAS: 2260791-14-6
    Purity: >99.00%

    OSMI-4 is a potent O-GlcNAc transferase (OGT) inhibitor, with an EC 50 value of 3μM.

  • GC31548 structure
    GC31548ACAT-IN-1 cis isomer
    CAS: 145961-79-1
    Purity: >98%

    ACAT-IN-1 cis isomer is a potent ACAT inhibitor with an IC50 of 100 nM.