Chrysosplenetin (Synonyms: Chrysosplenol B, Chrysosptertin B, EMD 20940, Polycladin) |
| رقم الكتالوجGC35692 |
Chrysosplenetin هو أحد مركبات الفلافونويد متعددة الميثوكسيل في Artemisia annua L
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Cas No.: 603-56-5
Sample solution is provided at 25 µL, 10mM.
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Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A[1]. CYP3A
[1]. Ma L, et al. Chrysosplenetin inhibits artemisinin efflux in P-gp-over-expressing Caco-2 cells and reverses P-gp/MDR1 mRNA up-regulated expression induced by artemisinin in mouse small intestine. Pharm Biol. 2017 Dec;55(1):374-380.
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