2,2,5,7,8-Pentamethyl-6-Chromanol |
رقم الكتالوجGC35069 |
2،2،5،7،8-Pentamethyl-6-Chromanol (PMC) هو جزء مضاد للأكسدة لفيتامين E (α-tocopherol)يحتوي 2،2،5،7،8-Pentamethyl-6-Chromanol على تعديل إشارات لمستقبلات الأندروجين (AR) ونشاط مضاد للسرطان ضد خطوط خلايا سرطان البروستاتا
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Cas No.: 950-99-2
Sample solution is provided at 25 µL, 10mM.
2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) is the anti-oxidant moiety of vitamin E (α-tocopherol). 2,2,5,7,8-Pentamethyl-6-Chromanol has potent androgen receptor (AR) signaling modulation and anti-cancer activity against prostate cancer cell lines[1].
[1]. Kyriakopoulos CE, et al. A multicenter phase 1/2a dose-escalation study of the antioxidant moiety of vitamin E 2,2,5,7,8-pentamethyl-6-chromanol (APC-100) in men with advanced prostate cancer. Invest New Drugs. 2016 Apr;34(2):225-30.
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