Longdaysin |
| رقم الكتالوجGC34650 |
Longdaysin هو مثبط لمسار إشارات Wnt / β-catenin ، والذي يمارس تأثير مضاد للورم من خلال حظر إشارات Wnt المعتمدة على CK1δ /يثبط Longdaysin CK1α و CK1δ و CDK7 و ERK2 مع IC50s 5.6 ميكرومتر و 8.8 ميكرومتر و 29 ميكرومتر و 52 ميكرومتر على التوالي
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1353867-91-0
Sample solution is provided at 25 µL, 10mM.
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Longdaysin is a CK1α, CK1δ, and extracellular signal-regulated kinase 2 (ERK2) inhibitor with IC50s of 5.6 µM, 8.8 µM, and 52 µM, respectively[1][2]. CKIα|5.6 μM (IC50)|CKIδ|8.8 μM (IC50)|ERK2|52 μM (IC50)
[1]. 1.Griffett K, et al. The mammalian clock and chronopharmacology. Bioorganic & Medicinal Chemistry Letters, 2013, 23(7):1929-1934.. [2]. Hirota T, et al. High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase. PLoS Biol. 2010 Dec 14;8(12):e1000559.
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