GLPBio

Angiogenesis

Research Areas

Products Related to Angiogenesis(378)

  • GC43514 structure
    GC43514D-myo-Inositol-1,3,4,5,6-pentaphosphate (ammonium salt)
    Purity: >98.00%

    Inositol-1,3,4,5,6-pentaphosphate (Ins(1,3,4,5,6)P5) is one of the many inositol phosphate isomers that act as small, soluble second messengers in the transmission of cellular signals.

  • GC43515 structure
    GC43515D-myo-Inositol-1,3,4,5,6-pentaphosphate (sodium salt)
    Purity: >98.00%

    The phosphatidylinositol 3-kinase (PI3K)/Akt signal transduction pathway plays critical roles in cell growth and proliferation making it an attractive target for anticancer agents.

  • GC43727 structure
    GC43727Ganglioside GD1a mixture (sodium salt)
    CAS: 12707-58-3
    Purity: >98.00%

    Ganglioside GD1a is a sialic acid-containing glycosphingolipid found in brain, erythrocytes, bone marrow, testis, spleen, and liver.

  • GC43732 structure
    GC43732Ganglioside GM3 Mixture (sodium salt)
    CAS: 54827-14-4
    Purity: >98.00%

    Ganglioside GM3 is a monosialoganglioside that demonstrates antiproliferative and proapoptotic effects in tumor cells by modulating cell adhesion, proliferation, and differentiation.

  • GC43803 structure
    GC43803HA-1077 (hydrochloride)
    CAS: 203911-27-7
    Purity: >98.00%

    Fasudil (HA-1077؛ AT877) ثنائي هيدروكلوريد هو مثبط RhoA / ROCK غير محدد وله أيضًا تأثير مثبط على كينازات البروتين ، مع Ki 0.33 μ ؛ M لـ ROCK1 ، IC50s من 0.158 μ ؛ M و 4.58 &8888956 ؛ M و 4.58 &8888956 ؛ ؛ M ، 1.650 μ ؛ M لـ ROCK2 و PKA ، PKC ، PKG ، على التوالي. HA-1077 (هيدروكلوريد) هو أيضًا مضاد فعال لقناة Ca2+ وموسع للأوعية.

  • GC44290 structure
    GC44290NAADP (sodium salt)
    Purity: >95.00%

    Nicotinic acid adenine dinucleotide phosphate (NAADP) is a secondary messenger that induces calcium mobilization.

  • GC44358 structure
    GC44358Nebivolol O-β-D-Glucuronide
    Purity: >95.00%

    Nebivolol O-β-D-glucuronide is an active metabolite of the β1-adrenergic receptor antagonist nebivolol.

  • GC44465 structure
    GC44465NSC 12
    CAS: 102586-30-1
    Purity: >98.00%

    NSC 12 عبارة عن مصيدة خارج الخلية لعامل نمو الخلايا الليفية 2 (FGF2) التي تربط FGF2 وتتداخل مع تفاعلها مع FGFR1. يمنع NSC 12 تكاثر الخلايا السرطانية المختلفة المعتمدة على FGF في كل من المختبر والحي مع عدم وجود آثار سمية جهازية.

  • GC44475 structure
    GC44475NVP-BEZ235 (hydrochloride)
    CAS: 2319647-83-9
    Purity: >98.00%

    NVP-BEZ235 is a potent dual inhibitor of phosphatidylinositol 3-kinase (PI3K) and mTOR that is well tolerated, displays disease stasis when administered orally, and enhances the efficacy of other anticancer agents when used in in vivo combination studies.

  • GC44584 structure
    GC44584PD 168368
    CAS: 204066-82-0
    Purity: >95.00%

    PD 168368 هو مضاد قوي ، تنافسي ، وانتقائي لمستقبلات نيوروميدين B (NMB-R) مع Ki من 15-45 نانومترPD 168368 هو مستقبل Neuromedin B (NMBR ؛ IC50 = 96 نانومتر) / مستقبل الببتيد المطلق للغاسترين (GRPR IC50 = 3500 نانومتر)PD 168368 هو أيضًا ناهض FPR1 / FPR2 / FPR3 مختلط مع EC50s 0.57 و 0.24 و 2.7 نانومتر على التوالي

  • GC44800 structure
    GC44800Quininib
    CAS: 143816-42-6
    Purity: >98%

    A CysLT 1 and CysLT 2 receptor antagonist

  • GC44956 structure
    GC44956Streptochlorin
    CAS: 120191-51-7
    Purity: >98.00%

    Streptochlorin is a bacterial metabolite originally isolated from Streptomyces sp.

  • GC44966 structure
    GC44966Sucrose octasulfate (potassium salt)
    CAS: 73264-44-5
    Purity: >95.00%

    Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum-sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury.

  • GC45054 structure
    GC45054Tie2 Inhibitor 7
    CAS: 1020412-97-8
    Purity: >95.00%

    Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 μM..

  • GC45269 structure
    GC45269(±)10(11)-DiHDPA
    CAS: 1345275-22-0
    Purity: >98.00%

    (±)10(11)-DiHDPA is produced from cytochrome P450 epoxygenase action on docosahexaenoic acid.

  • GC45677 structure
    GC45677Anlotinib (hydrochloride)
    CAS: 1058157-76-8
    Purity: >98.00%

    A neuropeptide with diverse biological activities

  • GC45688 structure
    GC45688STX140
    CAS: 401600-86-0
    Purity: >98.00%

    An estrogen sulfamate

  • GC45767 structure
    GC45767Dovitinib-d8
    CAS: 1246819-84-0
    Purity: >99.00%

    Dovitinib-D8 (CHIR-258-D8) هو الديوتيريوم المسمى DovitinibDovitinib (CHIR-258) هو مثبط متعدد الأهداف للتيروزين كيناز مع IC50s من 1 ، 2 ، 8/9 ، 10/13/8 ، 27/210 نانومتر لـ FLT3 ، c-Kit ، FGFR1 / FGFR3 ، VEGFR1 / VEGFR2 / VEGFR3 و PDGFRα / PDGFRβ ، على التوالي

  • GC45769 structure
    GC45769Vandetanib-d6
    CAS: 1174683-49-8
    Purity: >99.00%

    Vandetanib-d6 (ZD6474-d6) هو الديوتيريوم المسمى VandetanibVandetanib (D6474) هو مثبط قوي ونشط عن طريق الفم لنشاط التيروزين كيناز VEGFR2 / KDR (IC50 = 40 نانومتر)يحتوي Vandetanib أيضًا على نشاط مقابل نشاط التيروزين كيناز لـ VEGFR3 / FLT4 (IC50 = 110 نانومتر) و EGFR / HER1 (IC50 = 500 نانومتر)

  • GC45798 structure
    GC45798Rhein-13C4
    CAS: 1189928-10-6
    Purity: >95.00%

    An internal standard for the quantification of rhein

  • GC45880 structure
    GC45880Cimetidine-d3
    CAS: 1185237-29-9
    Purity: >99.00%

    An internal standard for the quantification of cimetidine

  • GC45922 structure
    GC45922(±)11(12)-EET-d11 methyl ester
    Purity: >99.00%

    A neuropeptide with diverse biological activities

  • GC46304 structure
    GC46304(±)-Nebivolol-d4 (hydrochloride)
    CAS: 2701283-32-9
    Purity: >99.00%

    A neuropeptide with diverse biological activities

  • GC46474 structure
    GC4647418-Deoxyherboxidiene
    CAS: 1200128-66-0
    Purity: >70.00%

    18-Deoxyherboxidiene (RQN-18690A) هو مثبط قوي لتكوين الأوعية