Metabolism

Tanzawaic acid B is a fungal metabolite that has been found in Penicillium and has diverse biological activities.

Rosuvastatin EP impurity A is a potential impurity in commercial preparations of the HMG-CoA reductase inhibitor rosuvastatin.

GPX4 16 is an inhibitor of glutathione peroxidase 4 (GPX4).

FerroLOXIN-1 is an inhibitor of the 15-lipoxygenase-2 (15-LO-2) and phosphatidylethanolamine-binding protein 1 (PEBP1) catalytic complex.

Ferroptosis inducer 24 is an inducer of ferroptosis.

NSC 44625 is an inhibitor of carbonic anhydrase II (CAII; Ki = 63 nM for the human enzyme).

TASP0277308 is a sphingosine-1-phosphate receptor 1 (S1P1) antagonist (IC50 = 4.2 nM).

viFSP1 is a species-independent inhibitor of ferroptosis suppressor protein 1 (FSP1; IC50s = 34 and 83 nM for the human and mouse enzymes, respectively).

Etomidate-d5 is intended for use as an internal standard for the quantification of etomidate by GC- or LC-MS.

ABBV-CLS-484 is a dual inhibitor of protein tyrosine phosphatase 1N (PTP1N) and PTP2N (IC50s = 2.5 and 1.8 nM, respectively).

ENPP3 inhibitor 5J is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1) and ENPP3 (IC50s = 0.59 and 0.62 µM, respectively, for the human enzymes).

GSK205 is an inhibitor of transient receptor potential vanilloid 4 (TRPV4) and transient receptor potential ankyrin 1 (TRPA1; IC50s = 4.19 and 5.56 µM, respectively, for the rat channels).

18-hydroxy Oleoyl leucine-d7 is intended for use as an internal standard for the quantification of 18-hydroxy oleoyl leucine by GC- or LC-MS.

h-e5'NT Inhibitor 5C is an inhibitor of ecto-5'-nucleotidase, also known as CD73 (IC50s = 0.37 and 1.66 µM for the human and rat enzymes, respectively).

FA16 is a ferroptosis inducer and an inhibitor of the system xc- cystine/glutamate transporter.

Cholic acid 3-sulfate is a metabolite of the primary bile acid cholic acid .

Ferroptosis Inhibitor D1 هو زبال الجذور الحرة و مثبط الفيروبوتسيس.

تم تصميم Rhein-13C6 للاستخدام كمعيار داخلي لقياس كمية السيلين بواسطة GC-أو LC-MS.

ويُحفِّز E17241 التعبير ABCA1، الذي يشفِّر المورِّثات الناقلة 1 التي تربط ATP-الكاسيت ؛ العائلة الفرعية A (ABCA1).

ECSI#6 هو مثبط لناقل السيروتونين (SERT)، ناقل الدوبامين (DAT)، وناقل نورإبينفرين (NET).

Ppc-1 هو حمض الكينولينيكاربوكسيليك prenylated معزولة أصلا من P. pseudo-candidum التي لديها أنشطة بيولوجية متنوعة.

GAPDH Inhibitor Compound F8 هو مثبط تساهمي من GAPDH (IC50 = 39.31 μM).

TrkB Agonist Prodrug R13 (R13) هو شكل دواء أولي من منشط كيناز B المرتبط بالتروبوميوسين (TrkB) 7،8-dihydroxyflavon.

Pantothenate-AMC هو الركيزة الفلورية للفانين 1، وهو إنزيم يشارك في إعادة تدوير حمض ال -بانتوثينيك.