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Aryl Hydrocarbon Receptor

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Aryl Hydrocarbon Receptor (AhR or AHR or ahr or ahR) is a protein that in humans is encoded by the AHR gene. The aryl hydrocarbon receptor is a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic (aryl) hydrocarbons, and regulates xenobiotic-metabolizing enzymes such as cytochrome P450s, most notably cyp 1A1.

Aryl Hydrocarbon Receptor is a member of the family of basic helix-loop-helix transcription factors. AhR binds several exogenous ligands including natural plant flavonoids, polyphenolics and indoles, as well as synthetic polycyclic aromatic hydrocarbons and dioxin-like compounds. AhR is a cytosolic transcription factor that is normally inactive, binding to several co-chaperones. Upon ligand binding to chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the chaperones dissociate resulting in AhR translocating into the nucleus and dimerizing with ARNT (AhR nuclear translocator), leading to changes in gene transcription.

Products Related to Aryl Hydrocarbon Receptor(40)

  • GC10538 structure
    GC10538Pifithrin-α (PFTα)
    CAS: 63208-82-2
    Purity: >98.00%

    Pifithrin-α(PFT-α) is a p53 inhibitor.Pifithrin-α widely used in neuroscience to block neuronal apoptotic cell death.Pifithrin-α is also a potent stimulant of aryl hydrocarbon receptor (AhR).

  • GC11817 structure
    GC11817PDM 2
    CAS: 688348-25-6
    Purity: >98.50%

    potent and selective aryl hydrocarbon receptor (AhR) antagonist

  • GC12040 structure
    GC12040L-Kynurenine
    CAS: 2922-83-0
    Purity: >98.00%

    L-Kynurenine is a metabolite of L-tryptophan and an aryl hydrocarbon receptor (AhR) agonist.

  • GC12628 structure
    GC12628ITE
    CAS: 448906-42-1
    Purity: >99.00%

    ITE is an effective immunosuppressive endogenous aromatic hydrocarbon receptor (AhR) agonist, with a K i value of 3nM for binding to AHR.

  • GC16220 structure
    GC16220CH 223191
    CAS: 301326-22-7
    Purity: >98.00%

    CH 223191 is an effective and specific antagonist of the aryl hydrocarbon receptor (AhR), capable of inhibiting TCDD-mediated AhR nuclear translocation and DNA binding, and suppresses TCDD-induced luciferase activity, with an IC50 of 0.03 μM.

  • GC16368 structure
    GC16368Indole-3-carbinol
    CAS: 700-06-1
    Purity: >98.00%

    anticarcinogenic drug

  • GC17043 structure
    GC17043StemRegenin 1 (SR1)
    CAS: 1227633-49-9
    Purity: >98.00%

    StemRegenin 1 (SR1) is a potent aromatic hydrocarbon receptor (AhR) antagonist (IC 50 = 127nM).

  • GC18824 structure
    GC18824CAY10465
    CAS: 688348-33-6
    Purity: >98.00%

    The aryl hydrocarbon receptor (AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin, benzo[a]pyrene, and numerous polyaromatics from soot and coal tar.

  • GC30297 structure
    GC30297Mivotilate (YH439)
    CAS: 130112-42-4
    Purity: >98.00%

    Mivotilate (YH439) is a nontoxic, potent activator of the aryl hydrocarbon receptor (AhR), and acts as a hepatoprotective agent.

  • GC30646 structure
    GC30646Skatole(3-Methylindole)
    CAS: 83-34-1
    Purity: >99.50%

    Skatole(3-Methylindole) is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.

  • GC31732 structure
    GC31732Tapinarof (WBI 1001)
    CAS: 79338-84-4
    Purity: >99.50%

    Tapinarof (WBI 1001) (WBI-1001) is a natural aryl hydrocarbon receptor (AhR) agonist with an EC50 of 13 nM.

  • GC33314 structure
    GC333141,4-Chrysenequinone (Chrysene-1,4-dione)
    CAS: 100900-16-1
    Purity: >98%

    1,4-Chrysenequinone (Chrysene-1,4-dione), a polycyclic aromatic quinone, acts as an activator of aryl hydrocarbon receptor (AhR).

  • GC34597 structure
    GC34597GNF351
    CAS: 1227634-69-6
    Purity: >99.50%

    GNF351 is a full aryl hydrocarbon receptor (AHR) antagonist.

  • GC35271 structure
    GC35271BAY-218 (AHR antagonist 1)
    CAS: 2162982-11-6
    Purity: >99.00%

    BAY-218 (AHR antagonist 1) is a novel, selective, and potent AhR small molecule inhibitor. BAY-218 inhibits AhR nuclear translocation, dioxin response element (DRE)-luciferase reporter expression, and AhR-regulated target gene expression induced by both exogenous and endogenous AhR ligands.

  • GC35553 structure
    GC35553Brevifolincarboxylic acid
    CAS: 18490-95-4
    Purity: >99.50%

    Brevifolincarboxylic acid is extracted from Polygonum capitatum, has inhibitory effect on the aryl hydrocarbon receptor (AhR).

  • GC36043 structure
    GC36043FICZ
    CAS: 172922-91-7
    Purity: >98.00%

    FICZ (Formyl-indolo [3,2-b] carbazole), as an endogenous ligand for the aryl hydrocarbon receptor (AhR), can exert pleiotropic effects including protection against inflammation, fibrosis, and oxidative stress.

  • GC38059 structure
    GC38059Cardamonin
    CAS: 18956-16-6
    Purity: >98%

    A chalconoid with anti-inflammatory and anti-tumor activity

  • GC39284 structure
    GC39284ANI-7
    CAS: 931417-26-4
    Purity: >99.00%

    ANI-7 is an activator of aryl hydrocarbon receptor (AhR) pathway. ANI-7 inhibits the growth of multiple cancer cells, and potently and selectively inhibits the growth of MCF-7 breast cancer cells with a GI50 of 0.56 μM. ANI-7 induces CYP1-metabolizing mono-oxygenases by activating AhR pathway, and also induces DNA damage, checkpoint Kinase 2 (Chk2) activation, S-phase cell cycle arrest, and cell death in sensitive breast cancer cell lines.

  • GC39669 structure
    GC39669AHR antagonist 2
    CAS: 2338747-54-7
    Purity: >99.00%

    AHR antagonist 2 is a potent aryl hydrocarbon receptor (AHR) antagonist, extracted from patent WO2019101641A1, compound example 1, with IC50s of 0.885 and 2.03 nM for human and mouse AhR.

  • GC44686 structure
    GC44686Prochloraz
    CAS: 67747-09-5
    Purity: >98.00%

    Prochloraz is an imidazole antifungal that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death.

  • GC45705 structure
    GC45705D-Kynurenine
    CAS: 13441-51-5
    Purity: >98.50%

    D-kynurenine (D-KYN) is a metabolite of the bacterial amino acid D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine (3-HK).

  • GC47037 structure
    GC47037Carbidopa (hydrate)
    CAS: 38821-49-7
    Purity: >98.00%

    Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease.

  • GC50422 structure
    GC5042210-Cl-BBQ
    CAS: 23982-76-5
    Purity: >98%

    Potent aryl hydrocarbon receptor (AhR) agonist; orally bioavailable

  • GC60636 structure
    GC60636Benzyl butyl phthalate
    CAS: 85-68-7
    Purity: >97.00%

    Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs).