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BRD 4354

Catalog No.GC33331

BRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively.

Products are for research use only. Not for human use. We do not sell to patients.

BRD 4354 Chemical Structure

Cas No.: 315698-07-8

Size Price Stock Qty
5mg
$74.00
In stock
10mg
$130.00
In stock
25mg
$260.00
In stock
50mg
$445.00
In stock
100mg
$751.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Protocol

Cell experiment:

A549 adenocarcinoma cells were treated with BRD 4354 for 24 h at 10 μM, and the top 50 upregulated and top 50 down regulated genes are compared to other compound treatments involving drugs, bioactive compounds with established MoA, and novel synthetic compounds[1].

References:

[1]. Boskovic ZV, ET AL. Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile. ACS Chem Biol. 2016 Jul 15;11(7):1844-51.

Background

BRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively.

BRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with BRD4354 having half-maximum inhibitory concentrations (IC50) of 0.85 μM and 1.88 μM, respectively. BRD 4354 also inhibits HDACs 4, 6, 7, and 8 at higher concentrations (3.88-13.8 μM) but demonstrates less of an inhibitory effect on other class I HDACs 1, 2, and 3 (IC50>40 μM) [1].

[1]. Boskovic ZV, ET AL. Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile. ACS Chem Biol. 2016 Jul 15;11(7):1844-51.

Chemical Properties

Cas No. 315698-07-8 SDF
Canonical SMILES OC1=C2N=CC=CC2=C(Cl)C=C1C(N3CCN(CC)CC3)C4=CC=CN=C4
Formula C21H23ClN4O M.Wt 382.89
Solubility DMSO : 125 mg/mL (326.46 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.6117 mL 13.0586 mL 26.1172 mL
5 mM 0.5223 mL 2.6117 mL 5.2234 mL
10 mM 0.2612 mL 1.3059 mL 2.6117 mL
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Reviews

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Average Rating: 5 ★★★★★ (Based on Reviews and 19 reference(s) in Google Scholar.)

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