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Home >> Signaling Pathways >> DNA Damage/DNA Repair >> HDAC

HDAC

Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.

Products for  HDAC

  1. Cat.No. Product Name Information
  2. GC12667 4SC-202 Class I HDAC inhibitor 4SC-202 Chemical Structure
  3. GA20605 Ac-Lys-AMC Ac-Lys-AMC is cleaved by trypsin. Ac-Lys-AMC Chemical Structure
  4. GC34458 ACY-1083 ACY-1083 Chemical Structure
  5. GC10417 ACY-241 Selective and orally active HDAC6 inhibitor ACY-241 Chemical Structure
  6. GC19020 ACY-738 ACY-738 is a potent, selective and orally-bioavailable HDAC6 inhibitor, with an IC50s of 1.7 nM; ACY-738 also inhibits HDAC1, HDAC2, and HDAC3, with IC50s of 94, 128, and 218 nM. ACY-738 Chemical Structure
  7. GC30782 ACY-775 ACY-775 Chemical Structure
  8. GC30526 ACY-957 ACY-957 Chemical Structure
  9. GC12961 Apicidin A potent HDAC inhibitor Apicidin Chemical Structure
  10. GC14590 AR-42 (OSU-HDAC42)

    HDAC inhibitor,novel and potent

     AR-42 (OSU-HDAC42) Chemical Structure
  11. GC15962 Belinostat (PXD101)

    Hydroxamate-type HDAC inhibitor

     Belinostat (PXD101) Chemical Structure
  12. GC30763 Benzenebutyric acid (4-Phenylbutyric acid) An inhibitor of HDAC and endoplasmic reticulum (ER) stress Benzenebutyric acid (4-Phenylbutyric acid) Chemical Structure
  13. GC12074 BG45 Novel HDAC3-selective inhibitor BG45 Chemical Structure
  14. GC12822 BML-210(CAY10433) Novel HDAC inhibitor BML-210(CAY10433) Chemical Structure
  15. GC33331 BRD 4354 BRD 4354 Chemical Structure
  16. GC35551 BRD 4354 ditrifluoroacetate BRD 4354 ditrifluoroacetate Chemical Structure
  17. GC38742 BRD-6929 BRD-6929 Chemical Structure
  18. GC12484 BRD73954 potent and selective HDAC inhibitor BRD73954 Chemical Structure
  19. GC15410 Bufexamac COX inhibitor Bufexamac Chemical Structure
  20. GC12971 CAY10603

    potent and selective inhibitor of HDAC6

     CAY10603 Chemical Structure
  21. GC14058 CBHA HDAC inhibitor CBHA Chemical Structure
  22. GC11975 CHAPS Zwitterionic detergent for membrane proteins,nondenaturing CHAPS Chemical Structure
  23. GC16042 Chidamide A novel HDAC inhibitor Chidamide Chemical Structure
  24. GC13408 CI994 (Tacedinaline) HDAC inhibitor CI994 (Tacedinaline) Chemical Structure
  25. GC34165 Corin Corin Chemical Structure
  26. GC32565 CRA-026440 CRA-026440 Chemical Structure
  27. GC38412 Crotonoside Crotonoside Chemical Structure
  28. GC16008 CUDC-101

    Multitargeted HDAC inhibitor

     CUDC-101 Chemical Structure
  29. GC12115 CUDC-907

    Potent PI3K/HDAC inhibitor

     CUDC-907 Chemical Structure
  30. GC15830 Daminozide KDM2A inhibitor Daminozide Chemical Structure
  31. GC35893 Domatinostat Domatinostat Chemical Structure
  32. GC13706 Droxinostat Selective HDAC inhibitor Droxinostat Chemical Structure
  33. GC19129 EDO-S101 EDO-S101 is a pan HDAC inhibitor; inhibits HDAC1, HDAC2 and HDAC3 with IC50 values of 9, 9 and 25 nM, respectively. EDO-S101 Chemical Structure
  34. GC64191 Elevenostat Elevenostat Chemical Structure
  35. GC11625 Entinostat (MS-275,SNDX-275) HDAC1 and HDAC3 inhibitor Entinostat (MS-275,SNDX-275) Chemical Structure
  36. GC33050 Givinostat (ITF-2357) Givinostat (ITF-2357) Chemical Structure
  37. GC33159 Givinostat hydrochloride (ITF-2357 hydrochloride) Givinostat hydrochloride (ITF-2357 hydrochloride) Chemical Structure
  38. GC18402 GSK3117391 GSK3117391 Chemical Structure
  39. GC19190 HDAC-IN-4

    HDAC-IN-4 is a histone deacetylase (HDAC) inhibitor, extracted from patent WO/2007045844 A1 20070426.

     HDAC-IN-4 Chemical Structure
  40. GC33395 HDAC-IN-5 HDAC-IN-5 Chemical Structure
  41. GC41085 HDAC6 Inhibitor HDAC6 is a predominantly cytoplasmic enzyme that targets α-tubulin, cortactin, and heat shock protein 90, as well as other substrates. HDAC6 Inhibitor Chemical Structure
  42. GC33317 HDAC6-IN-1 HDAC6-IN-1 Chemical Structure
  43. GC19189 HDAC8-IN-1 HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM. HDAC8-IN-1 Chemical Structure
  44. GC12334 HNHA HDAC inhibitor HNHA Chemical Structure
  45. GC11574 HPOB HDAC6 inhibitor, potent and selective HPOB Chemical Structure
  46. GC17836 ITF2357 (Givinostat)

    HDAC inhibitor

     ITF2357 (Givinostat) Chemical Structure
  47. GC14597 ITSA-1 (ITSA1) HDAC activator via Trichostatin A (TSA) suppression ITSA-1 (ITSA1) Chemical Structure
  48. GC15476 JNJ-26481585

    Potent HDAC inhibitor

     JNJ-26481585 Chemical Structure
  49. GC13435 KD 5170 HDAC inhibitor KD 5170 Chemical Structure
  50. GC15114 LAQ824 (NVP-LAQ824,Dacinostat)

    HDAC inhibitor,potent and novel

     LAQ824 (NVP-LAQ824,Dacinostat) Chemical Structure
  51. GC13237 LMK 235 HDAC4/HDAC5 inhibitor LMK 235 Chemical Structure
  52. GC16456 M344 HDAC inhibitor,potent and cell-permeable M344 Chemical Structure
  53. GC15965 MC1568 Class II HDAC inhibitor,potent and selective MC1568 Chemical Structure
  54. GC11949 MI-192 inhibitor of histone deacetylases (HDACs) MI-192 Chemical Structure
  55. GC13055 Mocetinostat (MGCD0103, MG0103)

    HDAC inhibitor,isotype-selective and potent

     Mocetinostat (MGCD0103, MG0103) Chemical Structure
  56. GC15536 NCH 51 Histone deacetylase (HDAC) inhibitor NCH 51 Chemical Structure
  57. GC13764 Nexturastat A HDAC6 inhibitor,highly potent and selective Nexturastat A Chemical Structure
  58. GC32964 NKL 22 NKL 22 Chemical Structure
  59. GC15040 NSC 3852 HDAC inhibitor NSC 3852 Chemical Structure
  60. GC13925 Nullscript negative control of scriptaid, HDAC inhibitor Nullscript Chemical Structure
  61. GC11360 ORY-1001 Selective inhibitor of KDM1A. ORY-1001 Chemical Structure
  62. GC17472 Oxamflatin HADC inhibitor Oxamflatin Chemical Structure
  63. GC12257 Panobinostat (LBH589)

    HDAC inhibitor

     Panobinostat (LBH589) Chemical Structure
  64. GN10357 Parthenolide Parthenolide is a sesquiterpene lactone and active principle of feverfew (Chrysanthemum parthenium) Parthenolide Chemical Structure
  65. GC14682 PCI-24781 (CRA-024781) Pan-HDAC inhibitor PCI-24781 (CRA-024781) Chemical Structure
  66. GC18008 PCI-34051 HDAC8 inhibitor,potent and selective PCI-34051 Chemical Structure
  67. GC33115 Pomiferin (NSC 5113) Pomiferin (NSC 5113) Chemical Structure
  68. GC16734 Pracinostat (SB939)

    Pan-HDAC inhibitor

     Pracinostat (SB939) Chemical Structure
  69. GC11095 Pyroxamide HDAC1 inhibitor Pyroxamide Chemical Structure
  70. GC33290 Remetinostat (SHP-141) Remetinostat (SHP-141) Chemical Structure
  71. GC15879 Resminostat (RAS2410)

    Potent HDAC inhibitor

     Resminostat (RAS2410) Chemical Structure
  72. GC14243 Resminostat hydrochloride HDAC inhibitor Resminostat hydrochloride Chemical Structure
  73. GC10423 RG2833 Brain-penetrant HDAC inhibitor RG2833 Chemical Structure
  74. GC14285 RGFP966 Specific HDAC3 inhibitor RGFP966 Chemical Structure
  75. GC14998 Rocilinostat (ACY-1215) Selective HDAC6 inhibitor Rocilinostat (ACY-1215) Chemical Structure
  76. GC11334 Romidepsin (FK228, depsipeptide)

    HDAC1/HDAC2 inhibitor,potent and selective

     Romidepsin (FK228, depsipeptide) Chemical Structure
  77. GC14439 Santacruzamate A (CAY10683) HDAC inhibitor, potent and selective Santacruzamate A (CAY10683) Chemical Structure
  78. GC15172 SBHA HDAC1/HDAC3 inhibitor,cell-permeable SBHA Chemical Structure
  79. GC15315 Scriptaid HDAC inhibitor,novel and cell-permeable Scriptaid Chemical Structure
  80. GC31511 Sinapinic acid (Sinapic acid) Sinapinic acid (Sinapic acid) Chemical Structure
  81. GC15857 Sodium butyrate

    Histone deacetylase inhibitor

     Sodium butyrate Chemical Structure
  82. GC15002 Sodium Phenylbutyrate Histone deacetylase inhibitor Sodium Phenylbutyrate Chemical Structure
  83. GC38137 Splitomicin Splitomicin Chemical Structure
  84. GC19337 SR-4370 SR-4370 is an inhibitor of HDAC, with IC50s of 0.13 uM, 0.58 uM, 0.006 uM, 2.3 uM, and 3.4 uM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively. SR-4370 Chemical Structure
  85. GC14016 Sulforaphane

    Chemopreventive enzyme inducer via Keap1-Nrf2 signaling

     Sulforaphane Chemical Structure
  86. GC14340 Tasquinimod Antiangiogenic and antineoplastic agent Tasquinimod Chemical Structure
  87. GC13591 TC-H 106 HDAC inhibitor TC-H 106 Chemical Structure
  88. GC12019 TCS HDAC6 20b Selective HDAC6 inhibitor TCS HDAC6 20b Chemical Structure
  89. GC37753 Tefinostat Tefinostat Chemical Structure
  90. GC19406 TH34

    TH34 is a potent HDAC6/8/10 inhibitor

     TH34 Chemical Structure
  91. GC19360 TMP195 TMP195 is a selective class IIa histone deacetylase (HDAC) inhibitor with an IC50 of 300 nM. TMP195 Chemical Structure
  92. GC17703 TMP269 HDAC 4/5/7/9 inhibitor TMP269 Chemical Structure
  93. GC15526 Trichostatin A (TSA) A HDAC inhibitor Trichostatin A (TSA) Chemical Structure
  94. GC16386 Tubacin

    HDAC6 inhibitor,potent,selective,reversible,cell-permeable

     Tubacin Chemical Structure
  95. GC10839 Tubastatin A HDAC6 inhibitor,potent and selective Tubastatin A Chemical Structure
  96. GC10322 Tubastatin A HCl HDAC6 inhibitor,potent and selective Tubastatin A HCl Chemical Structure
  97. GC37845 Tucidinostat Tucidinostat Chemical Structure
  98. GC14367 UF 010 Novel and selective class I HDAC inhibitor UF 010 Chemical Structure
  99. GC11424 Valproic acid HDAC1 inhibitor Valproic acid Chemical Structure
  100. GC15794 Valproic acid sodium salt (Sodium valproate) HDAC inhibitor Valproic acid sodium salt (Sodium valproate) Chemical Structure
  101. GC64378 Valproic acid-d6 Valproic acid-d6 Chemical Structure

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