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Home >> Signaling Pathways >> DNA Damage/DNA Repair >> HDAC

HDAC

Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.

Products for  HDAC

  1. Cat.No. Product Name Information
  2. GC72591 (E,E)-RGFP966 (E,E)-RGFP966 is a selective and CNS permeable HDAC3 inhibitor that can be used for the research of Huntington’s disease. (E,E)-RGFP966 Chemical Structure
  3. GC73435 (S)-TNG260 (S)-TNG260 is an isomer of TNG260. (S)-TNG260 Chemical Structure
  4. GC12667 4SC-202 4SC-202 (4SC-202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). 4SC-202 Chemical Structure
  5. GC66055 5-Phenylpentan-2-one 5-Phenylpentan-2-one is a potent histone deacetylases (HDACs) inhibitor. 5-Phenylpentan-2-one can be used for urea cycle disorder research. 5-Phenylpentan-2-one Chemical Structure
  6. GA20605 Ac-Lys-AMC Ac-Lys-AMC is cleaved by trypsin. Ac-Lys-AMC Chemical Structure
  7. GC34458 ACY-1083

    ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor with an IC50 of 3 nM and is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY-1083 effectively reverses chemotherapy-induced peripheral neuropathy.

     ACY-1083 Chemical Structure
  8. GC10417 ACY-241

    Citarinostat

     ACY-241 (ACY241) is a second generation potent, orally active and high-selective HDAC6 inhibitor with an IC50 of 2.6 nM (IC50s of 35 nM, 45 nM, 46 nM and 137 nM for HDAC1, HDAC2, HDAC3 and HDAC8, respectively). ACY-241 has anticancer effects. ACY-241 Chemical Structure
  9. GC19020 ACY-738 ACY-738 is a potent, selective and orally-bioavailable HDAC6 inhibitor, with an IC50s of 1.7 nM; ACY-738 also inhibits HDAC1, HDAC2, and HDAC3, with IC50s of 94, 128, and 218 nM. ACY-738 Chemical Structure
  10. GC30782 ACY-775 An HDAC6 inhibitor ACY-775 Chemical Structure
  11. GC30526 ACY-957 ACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9. ACY-957 Chemical Structure
  12. GC65330 AES-135 AES-135, a hydroxamic acid-based pan-HDAC inhibitor, prolongs survival in an orthotopic mouse model of pancreatic cancer. AES-135 inhibits HDAC3, HDAC6, HDAC8, and HDAC11 with IC50s ranging from 190-1100 nM. AES-135 Chemical Structure
  13. GC67984 Alteminostat

    CKD-581

     Alteminostat Chemical Structure
  14. GC30763 Benzenebutyric acid (4-Phenylbutyric acid)

    4PBA

     Benzenebutyric acid (4-Phenylbutyric acid) (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research. Benzenebutyric acid (4-Phenylbutyric acid) Chemical Structure
  15. GC12074 BG45 Novel HDAC3-selective inhibitor BG45 Chemical Structure
  16. GC25139 Biphenyl-4-sulfonyl chloride

    p-Phenylbenzenesulfonyl chloride, 4-Phenylbenzenesulfonyl chloride, p-Biphenylsulfonyl chloride

     Biphenyl-4-sulfonyl chloride (p-Phenylbenzenesulfonyl, 4-Phenylbenzenesulfonyl, p-Biphenylsulfonyl) is a HDAC inhibitor with synthetic applications in palladium-catalyzed desulfitative C-arylation. Biphenyl-4-sulfonyl chloride Chemical Structure
  17. GC12822 BML-210(CAY10433)

    NphenylN'(2Aminophenyl)hexamethylenediamide, CAY10433

     BML-210(CAY10433) is a novel HDAC inhibitor, and its mechanism of action has not been characterized. BML-210(CAY10433) Chemical Structure
  18. GC33331 BRD 4354 BRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively. BRD 4354 Chemical Structure
  19. GC35551 BRD 4354 ditrifluoroacetate BRD 4354 (ditrifluoroacetate) is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively. BRD 4354 ditrifluoroacetate Chemical Structure
  20. GC38742 BRD-6929

    JQ12

     An HDAC1 and HDAC2 inhibitor BRD-6929 Chemical Structure
  21. GC72945 BRD2492 BRD2492 (compound 6d) is a potent, selective HDAC1 and HDAC2 inhibitor with IC50s of 13.2 nM and 77.2 nM, respecrtively. BRD2492 Chemical Structure
  22. GC12484 BRD73954 potent and selective HDAC inhibitor BRD73954 Chemical Structure
  23. GC15410 Bufexamac COX inhibitor Bufexamac Chemical Structure
  24. GC64761 Butyric acid-13C1 Butyric acid-13C1 Chemical Structure
  25. GC12971 CAY10603

    HDAC 6 inhibitor, Histone Deacetylase Inhibitor VIII

    potent and selective inhibitor of HDAC6

     CAY10603 Chemical Structure
  26. GC14058 CBHA

    Histone Deacetylase Inhibitor II,m-Carboxycinnamic Acid bis-Hydroxamide

     CBHA is a potent HDAC inhibitor, exhibiting ID50 values of 10 and 70 nM in vitro for HDAC1 and HDAC3, respectively. CBHA also induces apoptosis and suppresses tumor growth. CBHA Chemical Structure
  27. GC35668 CG-200745

    CG-200745

     CG-200745 (CG-200745) is an orally active, potent pan-HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. CG-200745 inhibits deacetylation of histone H3 and tubulin. CG-200745 induces the accumulation of p53, promotes p53-dependent transactivation, and enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins. CG-200745 enhances the sensitivity of Gemcitabine-resistant cells to Gemcitabine and 5-Fluorouracil (5-FU; ). CG-200745 induces apoptosis and has anti-tumour effects. CG-200745 Chemical Structure
  28. GC64942 CHDI-390576 CHDI-390576, a potent, cell permeable and CNS penetrant class IIa histone deacetylase (HDAC) inhibitor with IC50s of 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9, respectively, shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform. CHDI-390576 Chemical Structure
  29. GC16042 Chidamide

    CS 055, HBI 8000, Tucidinostat

     Chidamide (Chidamide impurity) is an impurity of Chidamide. Chidamide is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor. Chidamide Chemical Structure
  30. GC73933 CM-1758 CM-1758 is a histone deacetylase (HDAC) inhibitor. CM-1758 Chemical Structure
  31. GC65426 CM-675 CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 Chemical Structure
  32. GC34165 Corin Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC), with a Ki(inact) of 110 nM for LSD1 and an IC50 of 147 nM for HDAC1. Corin Chemical Structure
  33. GC32565 CRA-026440 CRA-026440 is a potent, broad-spectrum HDAC inhibitor. CRA-026440 Chemical Structure
  34. GC67674 CRA-026440 hydrochloride CRA-026440 hydrochloride Chemical Structure
  35. GC70432 Crebinostat Crebinostat is a potent histone deacetylase (HDAC) inhibitor with IC50 values of 0.7 nM, 1.0 nM, 2.0 nM and 9.3 nM for HDAC1, HDAC2, HDAC3 and HDAC6, respectively. Crebinostat Chemical Structure
  36. GC38412 Crotonoside

    2-Hydroxyadenosine, Isoguanine riboside, Isoguanosine, NSC 12161

     Crotonoside is a FLT3 and HDAC3/6 inhibitor that can be used to study acute myeloid leukemia (AML). Crotonoside Chemical Structure
  37. GC68988 DKFZ-748

    DKFZ-748 is a selective HDAC10 inhibitor (pIC50=7.66) with anti-tumor activity.

     DKFZ-748 Chemical Structure
  38. GC35893 Domatinostat Domatinostat (4SC-202 free base) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Domatinostat Chemical Structure
  39. GC19129 EDO-S101

    Tinostamustine

     EDO-S101 is a pan HDAC inhibitor; inhibits HDAC1, HDAC2 and HDAC3 with IC50 values of 9, 9 and 25 nM, respectively. EDO-S101 Chemical Structure
  40. GC64191 Elevenostat

    JB3-22

     Elevenostat (JB3-22) is a selective HDAC11 inhibitor (IC50=0.235??M). Anti-multiple myeloma (MM) activity. Elevenostat Chemical Structure
  41. GC73828 F-SAHA

    p-Fluoro-SAHA

     F-SAHA is a HDAC inhibitor (HDACi) and its 18F labeled derivative can be used in tumor imaging research. F-SAHA Chemical Structure
  42. GC65206 FT895 FT895 is a potent and selective HDAC11 inhibitor with an IC50 of 3 nM. FT895 Chemical Structure
  43. GC33050 Givinostat (ITF-2357) Givinostat (ITF-2357) (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF-2357) Chemical Structure
  44. GC33159 Givinostat hydrochloride (ITF-2357 hydrochloride)

    ITF-2357 hydrochloride

     Givinostat (ITF-2357) hydrochloride is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat hydrochloride (ITF-2357 hydrochloride) Chemical Structure
  45. GC18402 GSK3117391 GSK3117391 is a histone deacetylase (HDAC) inhibitor, extracted from patent WO/2008040934 A1. GSK3117391 Chemical Structure
  46. GC70965 HD-TAC7 HD-TAC7 is a potent PROTAC HDAC degrader with IC50 values of 3.6 μM, 4.2 μM and 1.1 μM for HDAC1, HDAC2 and HDAC3, respectively. HD-TAC7 Chemical Structure
  47. GC19190 HDAC-IN-4

    AZD 9468

     HDAC-IN-4 is a potent, selective and orally active class I HDAC inhibitor with IC50s of 63 nM, 570 nM and 550 nM for HDAC1, HDAC2 and HDAC3, respectively. HDAC-IN-4 has no activity against HDAC class II. HDAC-IN-4 has antitumor activity. HDAC-IN-4 Chemical Structure
  48. GC66052 HDAC-IN-40 HDAC-IN-40 is a potent alkoxyamide-based HDAC inhibitor with Ki values of 60 nM and 30 nM for HDAC2 and HDAC6, respectively. HDAC-IN-40 had antitumor effects. HDAC-IN-40 Chemical Structure
  49. GC33395 HDAC-IN-5 HDAC-IN-5 is a histone deacetylase (HDAC) inhibitor. HDAC-IN-5 Chemical Structure
  50. GC73392 HDAC-IN-52 HDAC-IN-52 is a pyridine-containing HDAC inhibitor, with IC50s of 0.189, 0.227, 0.440 and 0.446 μM for HDAC1, HDAC2, HDAC3, and HDAC10, respectively. HDAC-IN-52 Chemical Structure
  51. GC73627 HDAC/JAK/BRD4-IN-1 HDAC/JAK/BRD4-IN-1(compound 25ap) is a potent HDAC/JAK/BRD4 triple inhibitor. HDAC/JAK/BRD4-IN-1 Chemical Structure
  52. GC69210 HDAC10-IN-1

    HDAC10-IN-1 (compound 13b) is an effective and highly selective inhibitor of HDAC10, with an IC50 of 58 nM. HDAC10-IN-1 can regulate autophagy in invasive FLT3-ITD positive acute myeloid leukemia cells.

     HDAC10-IN-1 Chemical Structure
  53. GC68010 HDAC3-IN-T247 HDAC3-IN-T247 Chemical Structure
  54. GC73385 HDAC6 degrader-3 HDAC6 degrader-3 is a potent and selective HDAC6 degrader via ternary complex formation and the ubiquitin-proteasome pathway with a DC50 value of 19.4 nM. HDAC6 degrader-3 Chemical Structure
  55. GC41085 HDAC6 Inhibitor

    Histone Deacetylase 6

     HDAC6 Inhibitor is a potent and selective HDAC6 inhibitor (IC50=36 nM). HDAC6 Inhibitor weakly inhibits other HDAC isoforms. HDAC6 Inhibitor inhibits acyl-tubulin accumulation in cells with an IC50 value of 210 nM. HDAC6 Inhibitor Chemical Structure
  56. GC33317 HDAC6-IN-1 HDAC6-IN-1 is a potent and selective inhibitor for HDAC6 with an IC50 of 17 nM and shows 25-fold and 200-fold selectivity relative to HDAC1 (IC50=422 nM) and HDAC8 (IC50=3398 nM), respectively. HDAC6-IN-1 Chemical Structure
  57. GC73337 HDAC6-IN-13 HDAC6-IN-13 (Compound 35m) is a potent, highly selective, orally active HDAC6 inhibitor with an IC50 of 0.019 μM. HDAC6-IN-13 Chemical Structure
  58. GC73628 HDAC6-IN-23 HDAC6-IN-23 (compound 9) is an orally active HDAC6 inhibitor. HDAC6-IN-23 Chemical Structure
  59. GC73731 HDAC6-IN-26 HDAC6-IN-26 (compound 23) is a potent inhibitor of HDAC6. HDAC6-IN-26 Chemical Structure
  60. GC19189 HDAC8-IN-1

    MDK-7933

     HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM. HDAC8-IN-1 Chemical Structure
  61. GC65460 HDACs/mTOR Inhibitor 1 HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies, with IC50s of 0.19 nM, 1.8 nM, 1.2 nM and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα, respectively. HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in G0/G1 phase and induce tumor cell apoptosis with low toxicity in vivo. HDACs/mTOR Inhibitor 1 Chemical Structure
  62. GC73263 HFY-4A HFY-4A is a HDAC inhibitor. HFY-4A Chemical Structure
  63. GC12334 HNHA

    Histone Deacetylase Inhibitor VI

     HDAC inhibitor HNHA Chemical Structure
  64. GC11574 HPOB HDAC6 inhibitor, potent and selective HPOB Chemical Structure
  65. GC73712 ITF 3756 ITF 3756 is a potent and selective HDAC6 inhibitor. ITF 3756 Chemical Structure
  66. GC14597 ITSA-1 (ITSA1) ITSA-1 (ITSA1) is an activator of histone deacetylase (HDAC), and counteract trichostatin A (TSA)-induced cell cycle arrest, histone acetylation, and transcriptional activation. ITSA-1 (ITSA1) Chemical Structure
  67. GC34629 J22352 J22352 is a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC50 value of 4.7 nM. J22352 promotes HDAC6 degradation and induces anticancer effects by inhibiting autophagy and eliciting the antitumor immune response in glioblastoma cancers, and leading to the restoration of host antitumor activity by reducing the immunosuppressive activity of PD-L1. J22352 Chemical Structure
  68. GC64959 JAK/HDAC-IN-1 JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor, exhibits antiproliferative and proapoptotic activities in several hematological cell lines. JAK/HDAC-IN-1 shows IC50s of 4 and 2 nM for JAK2 and HDAC, respectively. JAK/HDAC-IN-1 Chemical Structure
  69. GC73112 JPS014 TFA JPS014 TFA is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS014 TFA Chemical Structure
  70. GC73113 JPS016 TFA JPS016 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS016 TFA Chemical Structure
  71. GC73594 KH16 KH16 is a potent and low nanomolar HDAC inhibitor. KH16 Chemical Structure
  72. GC25552 KT-531 KT-531 (KT531) is a potent, selective HDAC6 inhibitor with IC50 of 8.5 nM, displays 39-fold selectivity over other HDAC isoforms. KT-531 Chemical Structure
  73. GC74062 LSD1/HDAC6-IN-2 LSD1/HDAC6-IN-2 (JBI-802) is an orally active LSD1/HDAC6/MAO-A inhibitor, with IC50 values of 5 nM, 11 nM, and 5 nM, respectively. LSD1/HDAC6-IN-2 Chemical Structure
  74. GC73848 Martinostat hydrochloride Martinostat (drochloride) is a inhibitor of HDAC that can be labeled with radionuclides for diagnostic applications. Martinostat hydrochloride Chemical Structure
  75. GC11949 MI-192 inhibitor of histone deacetylases (HDACs) MI-192 Chemical Structure
  76. GC64729 MPT0B390 MPT0B390 is an arylsulfonamide-based derivative with potent HDAC inhibitory ability. MPT0B390, TIMP3 inducer, inhibits tumor growth, metastasis and angiogenesis. MPT0B390 shows antiproliferative activity against human colon cancer cell line HCT116 with the GI50 of 0.03 μM. MPT0B390 Chemical Structure
  77. GC65965 MPT0E028 MPT0E028 is an orally active and selective HDAC inhibitor with IC50s of 53.0 nM, 106.2 nM, 29.5 nM for HDAC1, HDAC2 and HDAC6, respectively. MPT0E028 reduces the viability of B-cell lymphomas by inducing apoptosis and possesses potent direct Akt targeting ability and reduces Akt phosphorylation in B-cell lymphoma. MPT0E028 has good anticancer activity. MPT0E028 Chemical Structure
  78. GC36690 Nampt-IN-3 Nampt-IN-3 (Compound 35) simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and HDAC with IC50s of 31 nM and 55 nM, respectively. Nampt-IN-3 effectively induces cell apoptosis and autophagy and ultimately leads to cell death. Nampt-IN-3 Chemical Structure
  79. GC36691 Nanatinostat

    CHR-3996

     Nanatinostat (CHR-3996) is a potent, class I selective and orally active histone deacetylase (HDAC) inhibitor with an IC50 of 8 nM. Nanatinostat Chemical Structure
  80. GC13764 Nexturastat A HDAC6 inhibitor,highly potent and selective Nexturastat A Chemical Structure
  81. GC32964 NKL 22

    Histone Deacetylase Inhibitor IV

     A selective HDAC1/3 inhibitor NKL 22 Chemical Structure
  82. GC71080 NT160 NT160 is a highly potent class-IIa HDAC inhibitor with an IC50 value of 0.046 μM. NT160 Chemical Structure
  83. GC13925 Nullscript negative control of scriptaid, HDAC inhibitor Nullscript Chemical Structure
  84. GC11360 ORY-1001

    Iadademstat, RG-6016

     Selective inhibitor of KDM1A. ORY-1001 Chemical Structure
  85. GC17472 Oxamflatin

    Metacept 3

     HADC inhibitor Oxamflatin Chemical Structure
  86. GC73287 PB131 PB131 is a selective and brain-permeable HDAC6 inhibitor with high binding affinity (IC50: 1.8 nM). PB131 Chemical Structure
  87. GC71101 PB94 PB94 is a selective HDAC11 inhibitor (IC50=108 nM). PB94 Chemical Structure
  88. GC73268 PH14 PH14 is a dual PI3K/HDAC inhibitor with IC50 values of 20.3 nM and 24.5 nM for PI3Kα and HDAC3, respectively. PH14 Chemical Structure
  89. GC36905 PI3K/HDAC-IN-1 PI3K/HDAC-IN-1 is a potent dual inhibitor of PI3K/HDAC, potently inhibits PI3Kδ and HDAC1 with IC50s of 8.1 nM and 1.4 nM, respectively. PI3K/HDAC-IN-1 Chemical Structure
  90. GC68474 Pivanex

    AN-9; Pivalyloxymethyl butyrate

     Pivanex Chemical Structure
  91. GC33115 Pomiferin (NSC 5113) Pomiferin (NSC 5113) (NSC 5113) acts as an potential inhibitor of HDAC, with an IC50 of 1.05 μM, and also potently inhibits mTOR (IC50, 6.2 μM). Pomiferin (NSC 5113) Chemical Structure
  92. GC33290 Remetinostat (SHP-141)

    SHP-141

     Remetinostat (SHP-141) (SHP-141) is a hydroxamic acid-based inhibitor of histone deacetylase enzymes (HDAC) which is under development for the treatment of cutaneous T-cell lymphoma. Remetinostat (SHP-141) Chemical Structure
  93. GC14285 RGFP966

    RGFP 966;RGFP-966

     RGFP966 is an N-(o-aminophenyl) carboxamide HDAC inhibitor with an IC50 of 0.08 μM for HDAC3, It is a class of slow on/slow off competitive tight binding inhibitors targeting HDAC3. RGFP966 Chemical Structure
  94. GC14439 Santacruzamate A (CAY10683)

    Santacruzamate A

     Santacruzamate A (CAY10683) (CAY-10683) is a potent and selective HDAC2 inhibitor with an IC50 of 119 pM. Santacruzamate A (CAY10683) Chemical Structure
  95. GC64684 SB-429201 SB-429201 is a potent and selective HDAC1 (IC50~1.5 μM). SB-429201 displays at least a 20-fold preference for HDAC1 inhibition over HDAC3 and HDAC8. SB-429201 Chemical Structure
  96. GC73944 SE-7552 SE-7552, a 2-(difluorometl)-1,3,4-oxadiazole (DFMO) derivative, is an orally active, highly selective, non-droxamate HDAC6 inhibitor with an IC50 of 33 nM. SE-7552 Chemical Structure
  97. GC74007 SelSA SelSA is a selective, orally active inhibitor for histone deacetylase 6 (HDAC6) with IC50 of 56.9 nM. SelSA Chemical Structure
  98. GC31511 Sinapinic acid (Sinapic acid)

    NSC 59261, Sinapinic Acid

     Sinapinic acid (Sinapic acid) (Sinapic acid) is a phenolic compound isolated from Hydnophytum formicarum Jack. Sinapinic acid (Sinapic acid) Chemical Structure
  99. GC37643 SIS17 SIS17 is a mammalian histone deacetylase 11 (HDAC 11) inhibitor with an IC50 value of 0.83 μM, inhibits the demyristoylation HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs. SIS17 Chemical Structure
  100. GC69917 Snail/HDAC-IN-1

    Snail/HDAC-IN-1 is an effective dual-target inhibitor of Snail/HDAC. It has strong inhibitory activity against HDAC1 with an IC50 of 0.405 μM and a strong inhibitory effect on Snail with a Kd of 0.18 μM. Snail/HDAC-IN-1 increases histone H4 acetylation in HCT-116 cells and reduces the expression of Snail protein, thereby inducing apoptosis in cells.

     Snail/HDAC-IN-1 Chemical Structure
  101. GC15857 Sodium butyrate

    Butyric Acid

    Histone deacetylase inhibitor

     Sodium butyrate Chemical Structure

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