HDAC

Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.

Cat.No. Product Name Information
GC12667 4SC-202 Class I HDAC inhibitor
GA20605 Ac-Lys-AMC Ac-Lys-AMC is cleaved by trypsin.
GC34458 ACY-1083
GC10417 ACY-241 Selective and orally active HDAC6 inhibitor
GC19020 ACY-738 ACY-738 is a potent, selective and orally-bioavailable HDAC6 inhibitor, with an IC50s of 1.7 nM; ACY-738 also inhibits HDAC1, HDAC2, and HDAC3, with IC50s of 94, 128, and 218 nM.
GC30782 ACY-775
GC30526 ACY-957
GC12961 Apicidin
Potent HDAC inhibitor
GC14590 AR-42 (OSU-HDAC42)
HDAC inhibitor,novel and potent
GC15962 Belinostat (PXD101)
Hydroxamate-type HDAC inhibitor
GC30763 Benzenebutyric acid (4-Phenylbutyric acid)
GC12074 BG45 Novel HDAC3-selective inhibitor
GC12822 BML-210(CAY10433) Novel HDAC inhibitor
GC33331 BRD 4354
GC35551 BRD 4354 ditrifluoroacetate
GC38742 BRD-6929
GC12484 BRD73954 potent and selective HDAC inhibitor
GC15410 Bufexamac COX inhibitor
GC12971 CAY10603
potent and selective inhibitor of HDAC6
GC14058 CBHA HDAC inhibitor