HDAC
Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.
Products for HDAC
- Cat.No. Product Name Information
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GC12667
4SC-202
Class I HDAC inhibitor
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GA20605
Ac-Lys-AMC
Ac-Lys-AMC is cleaved by trypsin.
-
GC34458
ACY-1083
-
GC10417
ACY-241
Selective and orally active HDAC6 inhibitor
-
GC19020
ACY-738
ACY-738 is a potent, selective and orally-bioavailable HDAC6 inhibitor, with an IC50s of 1.7 nM; ACY-738 also inhibits HDAC1, HDAC2, and HDAC3, with IC50s of 94, 128, and 218 nM.
-
GC30782
ACY-775
-
GC30526
ACY-957
-
GC12961
Apicidin
A potent HDAC inhibitor
-
GC14590
AR-42 (OSU-HDAC42)
HDAC inhibitor,novel and potent
-
GC15962
Belinostat (PXD101)
Hydroxamate-type HDAC inhibitor
-
GC30763
Benzenebutyric acid (4-Phenylbutyric acid)
An inhibitor of HDAC and endoplasmic reticulum (ER) stress
-
GC12074
BG45
Novel HDAC3-selective inhibitor
-
GC12822
BML-210(CAY10433)
Novel HDAC inhibitor
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GC33331
BRD 4354
-
GC35551
BRD 4354 ditrifluoroacetate
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GC38742
BRD-6929
-
GC12484
BRD73954
potent and selective HDAC inhibitor
-
GC15410
Bufexamac
COX inhibitor
-
GC12971
CAY10603
potent and selective inhibitor of HDAC6
-
GC14058
CBHA
HDAC inhibitor
-
GC11975
CHAPS
Zwitterionic detergent for membrane proteins,nondenaturing
-
GC16042
Chidamide
A novel HDAC inhibitor
-
GC13408
CI994 (Tacedinaline)
HDAC inhibitor
-
GC34165
Corin
-
GC32565
CRA-026440
-
GC38412
Crotonoside
-
GC16008
CUDC-101
Multitargeted HDAC inhibitor
-
GC12115
CUDC-907
Potent PI3K/HDAC inhibitor
-
GC15830
Daminozide
KDM2A inhibitor
-
GC35893
Domatinostat
-
GC13706
Droxinostat
Selective HDAC inhibitor
-
GC19129
EDO-S101
EDO-S101 is a pan HDAC inhibitor; inhibits HDAC1, HDAC2 and HDAC3 with IC50 values of 9, 9 and 25 nM, respectively.
-
GC64191
Elevenostat
-
GC11625
Entinostat (MS-275,SNDX-275)
HDAC1 and HDAC3 inhibitor
-
GC33050
Givinostat (ITF-2357)
-
GC33159
Givinostat hydrochloride (ITF-2357 hydrochloride)
-
GC18402
GSK3117391
-
GC19190
HDAC-IN-4
HDAC-IN-4 is a histone deacetylase (HDAC) inhibitor, extracted from patent WO/2007045844 A1 20070426.
-
GC33395
HDAC-IN-5
-
GC41085
HDAC6 Inhibitor
HDAC6 is a predominantly cytoplasmic enzyme that targets α-tubulin, cortactin, and heat shock protein 90, as well as other substrates.
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GC33317
HDAC6-IN-1
-
GC19189
HDAC8-IN-1
HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM.
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GC12334
HNHA
HDAC inhibitor
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GC11574
HPOB
HDAC6 inhibitor, potent and selective
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GC17836
ITF2357 (Givinostat)
HDAC inhibitor
-
GC14597
ITSA-1 (ITSA1)
HDAC activator via Trichostatin A (TSA) suppression
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GC15476
JNJ-26481585
Potent HDAC inhibitor
-
GC13435
KD 5170
HDAC inhibitor
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GC15114
LAQ824 (NVP-LAQ824,Dacinostat)
HDAC inhibitor,potent and novel
-
GC13237
LMK 235
HDAC4/HDAC5 inhibitor
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GC16456
M344
HDAC inhibitor,potent and cell-permeable
-
GC15965
MC1568
Class II HDAC inhibitor,potent and selective
-
GC11949
MI-192
inhibitor of histone deacetylases (HDACs)
-
GC13055
Mocetinostat (MGCD0103, MG0103)
HDAC inhibitor,isotype-selective and potent
-
GC15536
NCH 51
Histone deacetylase (HDAC) inhibitor
-
GC13764
Nexturastat A
HDAC6 inhibitor,highly potent and selective
-
GC32964
NKL 22
-
GC15040
NSC 3852
HDAC inhibitor
-
GC13925
Nullscript
negative control of scriptaid, HDAC inhibitor
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GC11360
ORY-1001
Selective inhibitor of KDM1A.
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GC17472
Oxamflatin
HADC inhibitor
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GC12257
Panobinostat (LBH589)
HDAC inhibitor
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GN10357
Parthenolide
Parthenolide is a sesquiterpene lactone and active principle of feverfew (Chrysanthemum parthenium)
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GC14682
PCI-24781 (CRA-024781)
Pan-HDAC inhibitor
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GC18008
PCI-34051
HDAC8 inhibitor,potent and selective
-
GC33115
Pomiferin (NSC 5113)
-
GC16734
Pracinostat (SB939)
Pan-HDAC inhibitor
-
GC11095
Pyroxamide
HDAC1 inhibitor
-
GC33290
Remetinostat (SHP-141)
-
GC15879
Resminostat (RAS2410)
Potent HDAC inhibitor
-
GC14243
Resminostat hydrochloride
HDAC inhibitor
-
GC10423
RG2833
Brain-penetrant HDAC inhibitor
-
GC14285
RGFP966
Specific HDAC3 inhibitor
-
GC14998
Rocilinostat (ACY-1215)
Selective HDAC6 inhibitor
-
GC11334
Romidepsin (FK228, depsipeptide)
HDAC1/HDAC2 inhibitor,potent and selective
-
GC14439
Santacruzamate A (CAY10683)
HDAC inhibitor, potent and selective
-
GC15172
SBHA
HDAC1/HDAC3 inhibitor,cell-permeable
-
GC15315
Scriptaid
HDAC inhibitor,novel and cell-permeable
-
GC31511
Sinapinic acid (Sinapic acid)
-
GC15857
Sodium butyrate
Histone deacetylase inhibitor
-
GC15002
Sodium Phenylbutyrate
Histone deacetylase inhibitor
-
GC38137
Splitomicin
-
GC19337
SR-4370
SR-4370 is an inhibitor of HDAC, with IC50s of 0.13 uM, 0.58 uM, 0.006 uM, 2.3 uM, and 3.4 uM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively.
-
GC14016
Sulforaphane
Chemopreventive enzyme inducer via Keap1-Nrf2 signaling
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GC14340
Tasquinimod
Antiangiogenic and antineoplastic agent
-
GC13591
TC-H 106
HDAC inhibitor
-
GC12019
TCS HDAC6 20b
Selective HDAC6 inhibitor
-
GC37753
Tefinostat
-
GC19406
TH34
TH34 is a potent HDAC6/8/10 inhibitor
-
GC19360
TMP195
TMP195 is a selective class IIa histone deacetylase (HDAC) inhibitor with an IC50 of 300 nM.
-
GC17703
TMP269
HDAC 4/5/7/9 inhibitor
-
GC15526
Trichostatin A (TSA)
A HDAC inhibitor
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GC16386
Tubacin
HDAC6 inhibitor,potent,selective,reversible,cell-permeable
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GC10839
Tubastatin A
HDAC6 inhibitor,potent and selective
-
GC10322
Tubastatin A HCl
HDAC6 inhibitor,potent and selective
-
GC37845
Tucidinostat
-
GC14367
UF 010
Novel and selective class I HDAC inhibitor
-
GC11424
Valproic acid
HDAC1 inhibitor
-
GC15794
Valproic acid sodium salt (Sodium valproate)
HDAC inhibitor
-
GC64378
Valproic acid-d6