BX 430 (Synonyms: Blocker of P2X4 Compound 3.0) |
| Catalog No.GC50200 |
Selective P2X4 allosteric antagonist
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 688309-70-8
Sample solution is provided at 25 µL, 10mM.
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Selective P2X4 allosteric antagonist (IC50 = 0.54 μM). Exhibits >10-fold selectivity for human P2X4 receptors over P2X1, P2X2, P2X3, P2X5 and P2X7 receptors. Binds noncompetitively at extracellular allosteric site. Effective at human and zebrafish, but not mouse and rat P2X4 receptors.
Ase et al (2015) Identification and characterization of a selective allosteric antagonist of human P2X4 receptor channels Mol.Pharmacol. 87 606 PMID:25597706
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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