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2',3'-Dideoxyadenosine (Synonyms: ddA, ddAdo, NSC 98700)

Catalog No.GC33994

2',3'-Dideoxyadenosine is an inhibitor of HIV replication.

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2',3'-Dideoxyadenosine Chemical Structure

Cas No.: 4097-22-7

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10mg
$73.00
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Sample solution is provided at 25 µL, 10mM.

Description of 2',3'-Dideoxyadenosine

2',3'-Dideoxyadenosine is an inhibitor of HIV replication[1]. Antiretroviral activity[1]. Antiviral efficacy[1].

2',3'-Dideoxyadenosine inhibits HIV-1 and simian immunodeficiency virus (SIV) in MT-4 cells with EC50s of 5.27 and 5.3 μM, respectively. 2',3'-Dideoxyadenosine inhibits HIV-1 and HIV-2 in human T-lymphocyte CEM cells with EC50s of 4 μM and 8 μM, respectively. 2',3'-Dideoxyadenosine inhibits HIV-1 and HIV-2 in Molt 4/C8 cells with EC50s of 4 μM and 5.5 μM, respectively. 2',3'-Dideoxyadenosine inhibits HIV-1 and HIV-2 in C8166 cells with EC50s of 17 μM and 22 μM, respectively. 2',3'-Dideoxyadenosine inhibits murine sarcoma virus (MSV) in C3H/3T3 cells with an EC50 of 24 μM[1].

[1]. Balzarini J, et al. Conversion of 2',3'-dideoxyadenosine (ddA) and 2',3'-didehydro-2',3'-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus. FEBS Lett. 1997 Jun 30;410(2-3):324-8.

Chemical Properties of 2',3'-Dideoxyadenosine

Cas No. 4097-22-7 SDF
Synonyms ddA, ddAdo, NSC 98700
Canonical SMILES NC1=C(N=CN2[C@H]3CC[C@H](O3)CO)C2=NC=N1
Formula C10H13N5O2 M.Wt 235.24
Solubility Water: 100 mg/mL (425.10 mM); DMSO: 100 mg/mL (425.10 mM) Storage 4°C, protect from light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 2',3'-Dideoxyadenosine

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1 mg 5 mg 10 mg
1 mM 4.251 mL 21.2549 mL 42.5098 mL
5 mM 0.8502 mL 4.251 mL 8.502 mL
10 mM 0.4251 mL 2.1255 mL 4.251 mL
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In vivo Formulation Calculator (Clear solution) of 2',3'-Dideoxyadenosine

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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