C791-0064 is a RAD52 inhibitor. C791-0064 specifically binds to RAD52 and disrupts its single-strand annealing activity. C791-0064 specifically inhibits the proliferation of cancer cells with BRCA2 deficiency, inducing DNA damage and apoptosis ( apoptosis ). C791-0064 can be used for the study of BRCA mutation-related cancers (such as breast cancer and ovarian cancer ) [1].
References:
[1]. Yang Q, et al. Identification of a RAD52 Inhibitor Inducing Synthetic Lethality in BRCA2-Deficient Cancer Cells. Front Pharmacol. 2021 Apr 29;12:637825.
References:
[1]. Yang Q, et al. Identification of a RAD52 Inhibitor Inducing Synthetic Lethality in BRCA2-Deficient Cancer Cells. Front Pharmacol. 2021 Apr 29;12:637825.