CAY10723 is an inhibitor of protein arginine deiminase 2 (PAD2) that binds to PAD2 in a target engagement assay (EC50 = 9.5 μM in HEK293/PAD2 cells). It is 1.6-, 47-, and ~15-fold selective for PAD2 over PAD1, PAD3, and PAD4, respectively. CAY10723 inhibits histone H3 citrullination in HEK293/PAD2 cells (EC50 = 0.4 μM).
CAY10723
Catalog No.: GC43202Purity:>98.00%Synonyms: AFM30a, AMF30a
CAY10723 is a potent protein arginine deiminase 2 (PAD2) inhibitor and has excellent PAD2-selectivity.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2095107-57-4
500μgIn Stock
$156.00
1
1mgIn Stock
$296.00
1
5mgIn Stock
$1,012.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 500μg | $156.00 | In Stock | 1 | |
| 1mg | $296.00 | In Stock | 1 | |
| 5mg | $1,012.00 | In Stock | 1 |
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Citations
No citations are currently available for this product. Below are selected publications citing GlpBio products.
Nature641, 529–536 (2025)
Nature628, 630–638 (2024)
Nature632, 686–694 (2024)
Nature618, 1017–1023 (2023)
Nature610, 366–372 (2022)
Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
Science388(6745) (2025)
Science387(6739) (2025)
Science387(6734) (2025)
Cell Research35, 97–116 (2025)
Cell Research34, 683–706 (2024)
Cell Research33, 273–287 (2023)
Cell Research33, 546–561 (2023)
Cell Research33, 904–922 (2023)
Cell Research31, 1291–1307 (2021)
Description
Product Documents
Purity:>98.00%Appearance:A solid
Chemical Properties
CAS No.
2095107-57-4
Synonyms
AFM30a, AMF30a
SMILES
O=C(N[C@@H](CCCNC(CF)=N)C1=NC2=C(C=CC=C2OC)N1C)C3=C(C(NC4)=O)C4=CC=C3
Molecular Formula
C24H27FN6O3
Molecular Weight
466.5
Solubility
DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): 10 mg/ml
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
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