CB-096 |
Catalog No.GC52006
One-Click Copy Product Info
|
An inhibitor of RAN translation
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 108883-90-5
Sample solution is provided at 25 µL, 10mM.
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CB-096 is an inhibitor of repeat-associated non-ATG (RAN) translation.1 It selectively binds to the hexanucleotide GGGGCC repeat expansion (r(G4C2)exp) hairpin r(G4C2)8 (EC50 = 19 µM) over the anti-sense hairpin r(G2C4)8 and base-paired construct r(GGCC)10. CB-096 (25 µM) inhibits RAN translation and the formation of nuclear stress granules in HEK293T cells expressing r(G4C2)66 in an in vitro model of C9orf72 amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (c9ALS/FTD). It also induces relaxation of rat thoracic aortic rings pre-contracted with norepinephrine (EC50 = 1.81 µM) and decreases systolic arterial pressure in conscious spontaneously hypertensive rats when administered at a dose of 100 mg/kg.2
1.Ursu, A., Wang, K.W., Bush, J.A., et al.Structural features of small molecules targeting the RNA repeat expansion that causes genetically defined ALS/FTDACS Chem. Biol.15(12)3112-3123(2020) 2.Navarrete-VÁzquez, G., Hidalgo-Figueroa, S., Torres-Piedra, M., et al.Synthesis, vasorelaxant activity and antihypertensive effect of benzo[d]imidazole derivativesBioorg. Med. Chem.18(11)3985-3991(2010)
| Cas No. | 108883-90-5 | SDF | |
| Canonical SMILES | OC(C=CC(C(NC1=C2)=NC1=CC=C2[N+]([O-])=O)=C3)=C3OC | ||
| Formula | C14H11N3O4 | M.Wt | 285.3 |
| Solubility | DMF: 14 mg/mL,DMSO: 20 mg/mL,Ethanol: Slightly soluble,PBS (pH 7.2): 0.3 mg/mL | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.5051 mL | 17.5254 mL | 35.0508 mL |
| 5 mM | 701 μL | 3.5051 mL | 7.0102 mL |
| 10 mM | 350.5 μL | 1.7525 mL | 3.5051 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)