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CMPDA

Catalog No.GC13290

positive allosteric modulator of AMPA receptors

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CMPDA Chemical Structure

Cas No.: 380607-77-2

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10mg
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50mg
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

CMPDA is a positive allosteric modulator of AMPA receptors with EC50s of 45.4 ± 4.2 nM/63.4 ± 5.6 nM for GluA2i/GluA2o receptor.IC50 value: 45.4 ± 4.2 nM/63.4 ± 5.6 nM(GluA2i/GluA2o) [1]Target: AMPAR modulatorCMPDA was nearly equipotent at modulating the two isoforms of GluA2 receptors, whereas CMPDB displayed a modest preference for the flip splice variant. Similar to CX614, CMPDA slowed the rate of deactivation of GluA2o receptors approximately 2-fold but had no effect on GluA2i receptor deactivation [1].

References:
[1]. Timm DE, et al. Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation. Mol Pharmacol. 2011 Aug;80(2):267-80.

Chemical Properties

Cas No. 380607-77-2 SDF
Chemical Name N,N'-(1,4-phenylenebis(ethane-2,1-diyl))bis(propane-2-sulfonamide)
Canonical SMILES CC(S(NCCC1=CC=C(CCNS(C(C)C)(=O)=O)C=C1)(=O)=O)C
Formula C16H28N2O4S2 M.Wt 376.53
Solubility DMF: 30mg/mL,DMSO: 30mg/mL,Ethanol: 30mg/mL,PBS (pH 7.2): 10mg/mL Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.6558 mL 13.2792 mL 26.5583 mL
5 mM 0.5312 mL 2.6558 mL 5.3117 mL
10 mM 0.2656 mL 1.3279 mL 2.6558 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 26 reference(s) in Google Scholar.)

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