2-MSP(4-OMe)-5-HA-PEG8-VA-Exatecan is a Drug-linker conjugates for ADC consisting of the ADC Cytotoxin Exatecan and a linker. 2-MSP(4-OMe)-5-HA-PEG8-VA-Exatecan can be used for synthesis of ADCs [1].
In Vivo, 2-MSP(4-OMe)-5-HA-PEG8-VA-Exatecan (synthetic ADC-2) (1-10 mg/kg; i.v.; single dose) exhibits potent, selective anti-tumor activity against HER2-positive tumors and drug-resistant tumors in mice models[1].
References:
[1]. Wenqiang Qu, et al. Antibody Drug Conjugates with Linker Systems. CN120437319A. 2025-08-08
In Vivo, 2-MSP(4-OMe)-5-HA-PEG8-VA-Exatecan (synthetic ADC-2) (1-10 mg/kg; i.v.; single dose) exhibits potent, selective anti-tumor activity against HER2-positive tumors and drug-resistant tumors in mice models[1].
References:
[1]. Wenqiang Qu, et al. Antibody Drug Conjugates with Linker Systems. CN120437319A. 2025-08-08