Antcin K is a selective inhibitor targeting the PI3K/Akt, NF-κB, MEK1/2-ERK, p38 and AP-1 pathways. Antcin K upregulates IL-10 expression, thereby inhibiting the production of pro-inflammatory factors, blocking monocyte adhesion, reducing tissue damage, and promoting myogenesis. Antcin K has significant anti-inflammatory, anti-damage and tissue protective activities. Antcin K is mainly used in the research of inflammation-related diseases such as periodontitis, rheumatoid arthritis, and skeletal muscle injury [1] [2] [3].
References:
[1]. Wu YH, et al. Antcin K suppresses proinflammatory cytokines expression via the PI3K, Akt and NF-κB pathways in human gingival fibroblasts: implications for periodontitis treatment. Cell Death Discov. 2025 Nov 22.
[2]. Achudhan D, et al. Antcin K inhibits VCAM-1-dependent monocyte adhesion in human rheumatoid arthritis synovial fibroblasts. Food Nutr Res. 2022 Jun 2;66.
[3]. Chang TK, et al. Antcin K ameliorates cardiotoxin-induced skeletal muscle injury and inflammation via IL-10 regulation. Int J Biol Sci. 2025 Mar 19;21(6):2493-2507.
References:
[1]. Wu YH, et al. Antcin K suppresses proinflammatory cytokines expression via the PI3K, Akt and NF-κB pathways in human gingival fibroblasts: implications for periodontitis treatment. Cell Death Discov. 2025 Nov 22.
[2]. Achudhan D, et al. Antcin K inhibits VCAM-1-dependent monocyte adhesion in human rheumatoid arthritis synovial fibroblasts. Food Nutr Res. 2022 Jun 2;66.
[3]. Chang TK, et al. Antcin K ameliorates cardiotoxin-induced skeletal muscle injury and inflammation via IL-10 regulation. Int J Biol Sci. 2025 Mar 19;21(6):2493-2507.